Senior Scientist, siRNA Therapeutics & Delivery

ABBVIE; Cambridge (MA); On-site; USD 110,000 - 209,000; Full time

Job summary

AbbVie is seeking a Senior Scientist I/II to join the siRNA group within the Biotherapeutics and Genetic Medicine (BGM) organization. The role involves designing and executing innovative experimental approaches to advance oligonucleotide therapeutics and siRNA delivery for extrahepatic pipelines.

The successful candidate will lead cross-functional collaborations, develop multiple assay types, and contribute to publications and patent applications while mentoring junior scientists in a fast-paced

Job description

Senior Scientist, siRNA Therapeutics & Delivery

• Full-time
• Salary Min: 109500
• Salary Max: 208500
• Workday Global Grade: 18
• Travel: Yes, 5% of the Time
• Compensation: USD 109,500 - USD 208,500 - yearly

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking fortalented, passionate, and driven individuals to join our BiotherapeuticsandGenetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.

AbbVie is looking for a Senior Scientist I/IIto join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeuticsand to enable siRNA deliveryfor extrahepatic pipelinedevelopment.The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

Responsibilities:

• Lead research efforts within a cross-functional team to advance siRNAtherapeuticsdevelopmentfor ex-hepaticpipelines
• Design, evaluate,and develop novelex-hepaticsiRNA delivery platformsfor targeted delivery to tissues of interest
• Conceive and execute proof-of-concept experiments to validate scientific hypotheses and address technical challenges with high-quality results.
• Developin vitro,ex vivo, andin vivoassaysto assess siRNA candidates and delivery technologies in support of program objectives.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Acquire deep knowledge of RNA biology and siRNA therapeutics to support programs across multiple stages of development.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Mentor and support junior scientists within the team.

BS, MS, or PhD in molecular biology, RNA biology, cell biology, pharmaceutical sciences, biomedical engineering,or or a related scientific discipline, with typically 0-4+(PhD), 8-10+ (MS), or 10-12+ (BS) years of relevant experience.

Hands-on experience in designing and executingin vitroandin vivostudies to evaluate siRNA deliveryplatforms,includingassessments ofcellular uptake, target knockdown, delivery efficiency and biodistribution.

Demonstrated expertise in siRNA therapeutics, includingthedesign, development, characterization and optimizationofsiRNAsequences anddelivery systems.

Proven experiencewithsiRNAand antibody-oligo-conjugates (AOCs) is highly desirable.

Extensive hands-onexperience and techniques formolecular andRNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR,ddPCR),next-generation sequencing (NGS),protein quantification (ELISA, Western Blot, JESS), flowcytometryandother biomarker quantification.

Proven ability todevelop,troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.

Highly self-motivatedand capable ofthrivingin a fast-paced, collaborative team environment.

Strong written and verbal communication skills,withexperience contributing to technical reports, publications, or regulatory documentation.

Why AbbVie?
AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprogram.
• This job may be eligible toparticipatein our long-term incentiveprogram.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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