Senior Scientist, Real-World Evidence & Disease Genomics

Sanofi; Cambridge (MA); On-site; USD 149,000 - 215,000; Full time

Benefits offered by this job

Health benefits

Parental leave (14 weeks)

Diversity & Inclusion programs

Job summary

Sanofi in Cambridge, MA seeks a Senior Principal Scientist/Principal Scientist for Real-World Evidence and Disease Genomics to leverage large-scale EHRs and population biobanks, transforming disease trajectories and indication expansion opportunities.

You will develop EHR-based methods, define cohorts, engage with FinnGen/All of Us, and collaborate with disease-area experts to translate analytics into tangible patient impact within an agile R&D environment.

Qualifications

• Ph.D. in Biomedical Informatics, Epidemiology, Computational Biology, Human Genetics, or related field with 4+ years post-PhD experience.
• Excellent knowledge of longitudinal EHR datasets and OMOP CDM.
• Knowledge of target trial emulation methods and causal inference with observational data.
• Familiarity with GWAS and population-scale genomic analyses.
• Strong communication skills to present complex analyses to diverse stakeholders.

Responsibilities

• Lead indication prioritization and expansion using large-scale EHR data and biobanks.
• Develop and implement methods for longitudinal medical records analysis and target trial emulation.
• Define well-curated disease cohorts and progression endpoints using EHRs.
• Run GWAS in curated cohorts to identify genetic drivers of disease and response.
• Scale methods across FinnGen, All of Us, and other biobanks to support R&D.

Skills

EHR data analysis

OMOP CDM

GWAS methodology

AI-assisted coding tools

Communication skills

Agile environment

Biobank collaboration

Cloud platforms (AWS/GCP)

Cross-functional collaboration

Large-scale data pipelines

Education

PhD in Biomedical Informatics / Epidemiology / Computational Biology / Human Genetics or related field

Tools

Cursor

Claude Code

AWS

GCP

Job description

Sanofi in Cambridge, MA seeks a Senior Principal Scientist/Principal Scientist for Real-World Evidence and Disease Genomics to leverage large-scale EHRs and population biobanks, transforming disease trajectories and indication expansion opportunities.

You will develop EHR-based methods, define cohorts, engage with FinnGen/All of Us, and collaborate with disease-area experts to translate analytics into tangible patient impact within an agile R&D environment.