Architect, Real-World Evidence & Disease Genomics

Sanofi Group; Cambridge (MA); On-site; USD 149,000 - 215,000; Full time

Benefits offered by this job

Parental leave

Job summary

Sanofi Cambridge is hiring Senior Principal / Principal Scientist in Real-World Evidence & Disease Genomics. You will integrate EHR-derived real-world evidence with population genomics to inform disease trajectories, indication expansion, and R&D strategy across Sanofi assets.

You will develop scalable analytical pipelines, collaborate with cross-functional teams, and contribute to TREs/cloud computing workstreams while leveraging leading biobanks like FinnGen and All of Us.

Qualifications

• Ph.D. in Biomedical Informatics, Epidemiology, Computational Biology, Human Genetics, or a related field.
• 4+ years of post-PhD experience, preferably in biopharma/biotech.
• Hands-on experience with longitudinal EHR data and OMOP CDM.
• Knowledge of target trial emulation methods and causal inference.

Responsibilities

• Lead indication prioritization and expansion using target trial emulation from large-scale EHR datasets and biobanks.
• Develop methods for analysis of longitudinal medical records to evaluate drug effects on disease trajectories.
• Define and champion well-curated disease cohorts and progression endpoints from EHR data.
• Run GWAS in curated patient cohorts to identify genetic drivers of disease and drug response.
• Collaborate across cross-functional teams and scale methods to FinnGen/All of Us biobanks.

Skills

Longitudinal EHR data analysis

Target trial emulation

GWAS analysis

AI-assisted coding

Communication skills

Cloud computing (AWS/GCP)

TREs experience

Cross-functional collaboration

Population biobank experience

Education

Ph.D. in Biomedical Informatics, Epidemiology, Computational Biology, Human Genetics

Tools

Cursor

Claude Code

Job description

Sanofi Cambridge is hiring Senior Principal / Principal Scientist in Real-World Evidence & Disease Genomics. You will integrate EHR-derived real-world evidence with population genomics to inform disease trajectories, indication expansion, and R&D strategy across Sanofi assets.

You will develop scalable analytical pipelines, collaborate with cross-functional teams, and contribute to TREs/cloud computing workstreams while leveraging leading biobanks like FinnGen and All of Us.