Senior Scientist-R&D Oligo Synthesis

Grifols, S.A; San Diego (CA); On-site; USD 120,000 - 173,000; Full time

Benefits offered by this job

Health benefits

401(k) match

Job summary

Grifols Diagnostic Solutions in San Diego seeks a Scientist skilled in oligonucleotide chemistry to provide synthesis, purification, and analytical support for R&D projects. The role may lead subprojects, collaborate across teams, and present findings at scientific venues.

The candidate should have extensive lab experience in or related to oligonucleotide work, be able to communicate effectively, and contribute to core team projects within a dynamic R&D environment in California.

Qualifications

• Bachelor's degree in Molecular Biology, Chemistry, Biochemistry or related field.
• MS in Molecular Biology, Chemistry, Biochemistry or related field.
• PhD in Molecular Biology, Chemistry, Biochemistry or related field.
• 7-9 years post-baccalaureate laboratory experience; industrial experience preferred.
• PhD with post-doctoral or 4-6 years industrial experience preferred.

Responsibilities

• Perform automated oligonucleotide synthesis, deprotection and purification via standard phosphonamidite chemistry and chromatographic purification techniques.
• Conduct oligonucleotide analysis using LCMS, MALDI, UV/VIS, and HPLC/UPLC.
• Lead and execute complex experiments with design, analysis and data interpretation; deliverables.
• Collaborate with peers and cross-functional teams to share results and input.
• Maintain clearly written experimental records in written and electronic formats.
• Familiar with standard software tools used for instrument control, data analysis and reporting results.

Skills

Manage Execution

Realistic Planning

Promote Teamwork

Share the Vision

Make Sound Decisions

Education

Bachelor's degree in Molecular Biology

MS in Molecular Biology

PhD in Molecular Biology

Tools

LCMS

MALDI

Job description

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Would you like to join an international team working to improve the future of healthcare? Do you want to enhance the lives of millions of people? Grifols is a global healthcare company that since 1909 has been working to improve the health and well-being of people around the world. We are leaders in plasma-derived medicines and transfusion medicine and develop, produce and market innovative medicines, solutions and services in more than 110 countries and regions.

Grifols Diagnostic Solutions in San Diego is seeking a highly skilled and motivated Scientist who is passionate about utilizing their expertise in oligonucleotide chemistry to provide oligonucleotide synthesis, purification, and analysis for R&D projects. The candidate will be responsible for a significant portion of a complex project or an entire less complex project or multiple less complex projects. The ideal candidate should understand the scope of the overall project in the scope of corporate strategy. They may manage 1 or more personnel and may represent R&D on a Core Team for a product development project.

Duties and Responsibilities

This position will require automated synthesis of oligonucleotides, purification of oligonucleotides by chromatographic techniques and characterization of oligonucleotides by a variety of physicochemical techniques and conjugation of oligonucleotides by a variety of methods. The candidate may also participate in basic research projects exploiting novel properties of oligonucleotides in R&D assays. The candidate is expected to present work internally or at scientific conferences or write scientific papers. They are required to collaborate and communicate effectively with junior level employees, peers and cross-functional teams across all levels of the organization.

• Perform automated oligonucleotide synthesis, deprotection and purification via standard phosphonamidite chemistry and chromatographic purification techniques.
• Conduct oligonucleotide analysis using LCMS, MALDI, UV/VIS, and HPLC/UPLC techniques. Evaluate and identify impurities, degradation products, and synthesis by-products. Establish analytical protocols and support implementation of these protocols.
• Lead and execute complex experiments, including providing guidance and direction on experimental design, analysis and interpretation of data, communication of results, and design of follow-up experiments. Responsible for subproject or project goals and deliverables.
• Interact with peers and supervisors, both within the team as well as with other teams, to provide experimental summaries, design input, and ancillary team functions.
• Maintain clearly written experimental records in both written and electronic formats.
• Familiar with standard software tools utilized in instrument control, data analysis, and reporting results.

Knowledge, Skills, and Abilities

• Manage Execution: Conveys clear expectations for assignments, delegates enough of own work to others, monitors progress of others and redirects efforts when goals are not being met, continually looks for ways to improve processes, products, and/or services
• Build Realistic Plans: Develops realistic plans, actions steps and timetables for projects and assignments; identifies specific action steps and accountabilities, prepares realistic estimates of budget, staff and other resources
• Promote Teamwork: Promotes teamwork amongst groups: Discourages “we versus they” thinking, facilitates the discussion and resolution of different views; involves others in shaping plans and decisions that affect them; contributes to the efforts of the team’s work
• Share the Vision: Executes plans and develops strategies for achieving vision; Articulates the strategies to team(s) and others, manages people in a constructive manner to achieve strategic goals
• Make Sound Decisions: Makes timely decisions based on accurate logic; looks beyond symptoms to identify causes of problems and drives team to routinely perform root cause analyses; makes decisions in the face of uncertainty; takes all important issues into account when making decisions, including impact on people

Education

• B.A. / B.S. Molecular Biology, Chemistry, Biochemistry or related field
• M.S. Molecular Biology, Chemistry, Biochemistry or related field
• Ph.D. Molecular Biology, Chemistry, Biochemistry or related field

Experience

• 7-9 years post-baccalaureate laboratory experience. Industrial experience preferred.
• 6-8 years laboratory experience post-M.S. without thesis. Industrial experience preferred.
• 5-7 years laboratory experience post M.S. with thesis. Industrial experience preferred.
• Ph.D. with no post-doctoral research experience or 4-6 years industrial experience.
• Ph.D. with post-doctoral research experience and 3-5 years industrial experience.

The estimated pay scale for the Sr. Scientist role based in California, is $120,000.00 - $172,500.00 per year. Additionally, the position is eligible to participate in up to 15% of the company bonus pool. We offer a wide variety of benefits including, but not limited to: Medical, Dental, Vision, life insurance, PTO, paid holidays and up to 5% 401(K) match and tuition reimbursement. Final compensation packages will ultimately depend on education, experience, skillset, knowledge, where the role is performed, internal equity and market data. We are committed to offering our employees opportunities for professional growth and career progression. Grifols is a global healthcare organization with employees in 30 countries focused on patient health and providing impactful results. Since our humble beginnings in 1909, Grifols has been a family company that prides itself on its family-like culture. Our company has more than tripled over the last 10 years, and you can grow with us!

Grifols provides equal employment opportunities to applicants and employees without regard to race; color; sex; gender identity; sexual orientation; religious practices and observances; national origin; pregnancy, childbirth, or related medical conditions; status as a protected veteran or spouse/family member of a protected veteran; or disability. We will consider for employment all qualified applicants in a manner consistent with the requirements of all applicable laws, including but not limited to, the California Fair Chance Act, the Los Angeles County Fair Chance Ordinance for Employers, and the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.