Senior Scientist, Protein Assay Development – Spatial Biology

10x Genomics; Pleasanton (CA); On-site; USD 130,000 - 180,000; Full time

Job summary

10x Genomics seeks an exceptional scientist to drive spatial biology R&D, mapping proteins and biomolecules in intact tissues. You will apply cell biology, proteomics and immunology to optimize assays in a multi-disciplinary team spanning chemistry, software, engineering and microfluidics.

Applicants should have a PhD with 5+ years in proteomics and spatial imaging, plus hands-on experience with high-plex multiplexing and tissue processing.

Qualifications

• PhD in Molecular/Cell Biology, Immunology, Biochemistry or related field.
• 5+ years of experience in proteomics, imaging and spatial techniques, in situ hybridization.
• Hands-on experience with high-plex protein multiplexing technology.
• Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including surface markers or gene expression.
• Extensive experience working with antibodies, including mAb QC, conjugation, functional testing.
• Strong analytical background.
• Strong organizational skills.
• Strong written and oral communication skills.
• Strong troubleshooting and problem solving skills.
• Ability to work in a fast-paced and quickly changing environment.
• Desire to build game-changing technologies and impact the world of life science research.

Responsibilities

• Contribute to optimization of tissue handling and processing protocols for protein staining, including FFPE samples.
• Design and execute experiments using novel imaging and biochemistry platforms integral to various spatial technology platforms.
• Work closely with computational biologists and software engineers to interpret data.
• Develop robust protocols to be used internally across teams during product development.

Skills

Analytical thinking

Written & verbal communication

Troubleshooting

Antibody QC/Conjugation

High-plex multiplexing

Tissue processing & IHC

In situ hybridization

Data interpretation

Experiment design

Education

PhD in Molecular/Cell Biology, Immunology, Biochemistry or related field

Tools

R

Python

Omics data analysis software

Image analysis software

Job description

About the Role

We are looking for an exceptional, multidisciplinary scientist to drive new research and product development efforts in our Spatial Biology department, developing technologies that map protein - and other biomolecules - directly within intact tissue. The ideal candidate will have a proven track-tranck in cell biology, immunology or tumor biology with extensive experience designing and working with high-plex proteomics tissue imaging assays. This position requires a deep understanding of proteomics and cell biology as you will be applying your skills and knowledge to optimize and evaluate new assays in the area of spatial multiomics in tissues. Additionally, this role will require you to interact closely with colleagues in several departments including chemistry, computational biology, software, engineering and microfluidics. You should have a strong analytical background, be driven by developing revolutionary new products and technologies, and enjoy working in a fast-paced, innovative and truly multi-disciplinary environment. The successful candidate will contribute cell biology, proteomics and immunology expertise and leadership to cross-disciplinary product development teams to ensure project milestones and technological specifications are met.

What You Will Be Doing

• Contribute to the optimization of tissue handling and processing protocols for protein staining, including FFPE samples, to improve antigen retention, staining consistency, and compatibility with high-plex imaging workflows.


• Design and execute experiments using novel imaging and biochemistry platforms integral to various spatial technology platforms under development at 10x Genomics. This includes in-depth analysis and reporting of your data through documentation and presentations to internal groups.


• Work closely with computational biologists and software engineers to interpret data generated by novel optical and biochemical assays.


• Develop demonstrated and robust protocols that will be used internally across various teams during product development.

Minimum Requirements

• PhD in Molecular/Cell Biology, Immunology, Biochemistry or related field.


• 5+ years of relevant experience in proteomics, imaging and spatial techniques, in situ hybridization, preferably in the Biotechnology industry.


• Hands-on experience with high-plex protein multiplexing technology.


• Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including characterization by surface markers or gene expression.


• Extensive experience working with antibodies, including mAb QC, conjugation, functional testing.


• Strong analytical background


• Strong organizational skills.


• Strong written and oral communication skills.


• Strong troubleshooting and problem solving skills.


• Ability to work in a fast-paced and quickly changing environment.


• Desire to build game-changing technologies and impact the world of life science research.

Preferred Skills And Experience

• Pathology experience is a plus.


• Proficiency in R, Python, AI-aided coding or specialized omics data analysis software is a plus.


• Skills in image analysis are a plus

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company’s total compensation package.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.