Senior Scientist - Principle Scientist Mass Spec Core

KBI Biopharma; Boulder (CO); On-site; USD 118,000 - 148,000; Full time

Job summary

KBI Biopharma in Boulder, CO, seeks a Senior/Principal Analytical Scientist for its Analytical and Formulation Sciences team. The role focuses on protein analytics by LC-MS, with cross-functional collaboration spanning process development, characterization, and regulatory teams.

PhD required with extensive experience in biopharma analytics. Responsibilities include designing experiments, advancing analytical strategies, mentoring staff, and delivering regulatory-quality data for submissions.

Qualifications

• PhD in Biophysics, Biochemistry, Analytical Chemistry, Biochemical Engineering and 4+ years of experience for Senior; 6+ years for Principal.

Responsibilities

• Design and execute analytical experiments to support biotherapeutics process development.
• Demonstrate expertise in LC-MS, HPLC/UPLC and related analytical techniques.
• Develop strategies to support product development and regulatory submissions.
• Generate publication-ready documentation and regulatory-quality reports.
• Act as SME on client programs, guiding technical decisions and client interactions.
• Mentor junior scientists and review data and reports.

Skills

Scientific communication

Independent work

Team collaboration

Analytical thinking

Education

PhD in Biophysics, Biochemistry, Analytical Chemistry or Biochemical Engineering

Tools

LC-MS

HPLC/UPLC

Job description

At KBI Biopharma, we are advancing science and accelerating breakthroughs. As a global leader in biopharmaceutical development and manufacturing, we empower life science companies to bring new medicines and vaccines to the world faster. Explore your potential at KBI, where innovation meets impact.

Position Summary

KBI Biopharma is seeking a highly skilled and motivated Senior Level Analytical Scientist to join our Analytical and Formulation Sciences (AFS) team in Boulder, CO. This role is ideal for a PhD-level scientist with deep expertise in protein analytics by LC-MS. You will serve as a subject matter expert (SME), driving innovation and excellence in analytical testing by mass spectrometry to support integrated client programs from early development through commercialization. This position collaborates cross-functionally with process development, characterization, and regulatory teams.

Responsibilities

• Design and strategically execute analytical experiments in support of biotherapeutics Process Development.
• Demonstrate expertise in LC-MS, HPLC/UPLC, and other common analytical techniques.
• Design and implement analytical strategies to support product development and regulatory submissions.
• Generate high-quality documentation suitable for publication and regulatory review.
• Act as SME on client programs, providing technical guidance and representing KBI in client interactions.
• Mentor and train junior scientists and associates.
• Perform peer reviews of data and reports related to method development, qualification, and validation.
• Manage timelines and resources to meet project milestones.
• Advise leadership on program status and technical challenges.
• Contribute to continuous improvement initiatives within the AFS team.

Requirements

• Ph.D. in Biophysics, Biochemistry, Analytical Chemistry, Biochemical Engineering and 4+ years of experience for Senior Ph.D and 6+ years of experience for Principal.
• Able to react to change and handle other essential tasks as assigned.
• Adhere to all safety requirements and assure that departmental employees comply with required safety procedures.
• Strong understanding of protein structure, aggregation, and higher-order structure analysis.
• Excellent communication skills and ability to present complex data to diverse audiences.
• Proficiency in scientific software and data analysis tools.
• Ability to work independently and collaboratively in a fast-paced environment.
• Working knowledge of the Process Development functional area with aptitude in fermentation development for protein expression and downstream (purification) operations (chromatography, TFF, refold, conjugation) a plus.

Salary

Senior Scientist: $118,000-$148,000 Principal Scientist: $133,000-$167,000

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.

At KBI, we are constantly seeking to improve our team with accomplished individuals who share in our commitment to serve our clients as they seek to advance important medicines to the patients who need them.

We offer our employees a challenging, rewarding and fast-paced environment along with the opportunity for career advancement through the development of one’s technical skills.

At KBI, employees work in a collaborative, team environment, where sharing knowledge and expertise with one another is strongly encouraged.