Senior Scientist, Preclinical Translation

Seismictx; Massachusetts; On-site; USD 80,000 - 150,000; Full time

Job summary

An established industry player is seeking a Senior Scientist to drive innovative immunotherapy programs. This role focuses on drug metabolism and pharmacokinetics, requiring a deep scientific background and the ability to work on multiple projects. The ideal candidate will thrive in a fast-paced environment, collaborating with project teams and external stakeholders to optimize drug candidates. Join a supportive culture dedicated to improving patient outcomes through groundbreaking science and teamwork. If you're passionate about making a difference in healthcare, this opportunity is perfect for you.

Qualifications

• Ph.D. with 5+ years or MSc with 12+ years in drug metabolism.
• Strong understanding of ADME principles and PK/PD modeling.

Responsibilities

• Design PK/PD studies and lead DMPK efforts for drug optimization.
• Provide scientific leadership in discovering large molecule drug candidates.

Skills

Drug Metabolism and Pharmacokinetics (DMPK)

ADME Principles

PK/PD Modeling

Communication Skills

Teamwork

Education

Ph.D. in relevant field

MSc with 12+ years of experience

BSc with 15+ years of experience

Job description

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Senior Scientist, Preclinical Translation

Full Time Employee Professional Watertown, Watertown, MA, US

30+ days ago Requisition ID: 1048

Seismic is determined to help patients with unmet need by integrating machine learning, structural biology, protein engineering, and translational immunology to generate clinic-ready medicines. At our core, we are focused on phenomenal science, supportive culture, a diverse team, and patient-centric goals. We have an exciting opportunity for an experienced and motivated Senior Scientist to help drive novel immunotherapy programs. The candidate must be independent, goal oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic, and innovative individuals with a deep scientific background in drug metabolism and pharmacokinetics (DMPK) who thrive in a fast-paced, entrepreneurial environment.

Responsibilities:

• Work closely with project team leads to help design PK/PD studies and lead DMPK efforts to optimize molecules utilizing in vitro, in vivo, and in silico methods and models.
• Provide scientific leadership in the discovery of large molecule drug candidates by integrating DMPK strategy to progress drug discovery projects.
• Work closely with CROs and external stakeholders for all DMPK related activities.
• Help plan and analyze in vitro & in vivo experiments, as well as effectively communicate results to peers and senior leadership.
• Make independent decisions related to day-to-day experimental activities.

Basic Requirements

• Ph.D. with 5+ years, MSc with 12+ years or BSc with 15+ years of relevant experience.
• Excellent understanding of ADME principles with knowledge of PK/PD modeling of large molecules.
• Previous experience working with antibodies and Fc fusion proteins.
• Knowledge of bioassay development principles and data interpretation is preferred.
• Understanding of immunology, immunotherapy, and autoimmunity is preferred.
• Demonstrated ability to organize and clearly communicate complex data sets to peers and senior leadership.
• Scientifically rigorous but comfortable taking calculated risks with imperfect knowledge.
• Ability to work within a team, excellent verbal and written communication, and interpersonal skills.
• Self-motivated, conscientious, and passionate about improving patients’ lives.

What we offer you: As a member of our growing team, you will help us achieve the Preclinical Translation team’s impact and contributions. We not only take our scientific mission seriously but also provide a positive and supportive workplace environment and culture. Seismic will have the opportunity to benefit from the insight, diversity, and talent that you’ll bring. Together, we’ll help bring therapeutics to the patients who need them most.

Our mission: Seismic is determined to help patients in need, starting with novel approaches to protein engineering, machine learning, and immunology, and ending with clinic-ready drugs. At our core, our focus is on phenomenal science, meritocracy, a superstar team, supportive culture, and patient-centric goals. Success will enable treatment for millions of patients with currently incurable, often disabling and deadly diseases, and we invite you to become a part of that.

Seismic Therapeutic is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran's status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.