Senior Scientist-Method Development-Large Molecule Bioanalysis

ZipRecruiter; Exton (Chester County); On-site; USD 85,000 - 120,000; Full time

Job summary

A leading company in the CRO sector is seeking a Senior Method Development Scientist in Exton, PA. You will leverage your expertise in LC-MS/MS for method development of large molecules and support project management while ensuring compliance with industry standards. This position offers competitive compensation and a robust benefits package including health and dental insurance and a 401(k) plan.

Benefits

Health and dental insurance

401(k) plan

Short and long-term insurance

Life insurance

Qualifications

• 6-10 years experience in bioanalytical method development using LC-MS/MS.
• Experience with mass-spectrometry methods for large molecules.
• Good knowledge of GLP.

Responsibilities

• Develop methods using LC-MS/MS for large molecules.
• Facilitate method transfer from development to validation teams.
• Maintain regulatory compliance in bioanalytical services.

Skills

Analytical Chemistry

Biochemistry

Troubleshooting

Communication

Time Management

Teamwork

Education

Ph.D. or Master’s degree in Analytical Chemistry, Biochemistry, Biology

Job description

Job DescriptionJob Description

Title: Senior Method Development Scientist-Large Molecule Bioanalysis by LC-MS/MS

Location: 700 Pennsylvania Dr, Exton, PA

Reports to: Executive Director, Bioanalytical Services

Full-time/on-site

Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

Position/Job Summary:

The Senior method development scientist supports method development using LC-MS/MS platform for large molecules (proteins, antibodies, ADCs, Oligonucleotides, etc). The senior method development scientist will be a member of the method development team, the responsibility includes serving as subject matter expert when new proposal is received, reviewing the client request and evaluating the feasibility of the project, developing the method after the contract is signed, transferring the developed method to the validation team, and troubleshooting for challenging method.

Roles & Responsibilities:

• Develop method using LC-MS/MS platform for large molecules (Proteins, antibodies, ADC, Oligonucleotides, Liposomal drugs, etc) quantitation in biological matrices.
• Facilitate the method transfer from the Method development team with the method validation team.
• Communicate project timelines, status, and data to Principal Investigator effectively addressing any issues that may arise.
• Ability to work on multiple projects at the same time.
• Research literature and external sources and identify new techniques and procedures that strengthen Frontage’s capabilities.
• Maintain the proper level of regulatory compliance. Ensure that GLP regulations and SOPs are followed in all bioanalytical service activities.
• Help with training and/or mentoring of junior scientific staff.
• Set-up, utilize, and maintain complex instrumentation Follow safety precautions.

Education, Experience & Skills Required:

• Ph.D. or Master’s degree in Analytical Chemistry, Biochemistry, Biology or related scientific discipline.
• 6-10 years of direct experience of bioanalytical method development for large molecules using LC-MS/MS in the biotech, pharma or CRO industry.
• Demonstrated experience in mass-spectrometry method development for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis etc.
• Demonstrated experience in small molecule and protein mass-spectrometry of quantitation of antibody drug-conjugates (ADC), including total Antibody, Conjugated payload, and free payload.
• Experience with Oligonucleotides and liposomal drug quantitation using LC-MS/MS is a plus.
• Proven ability to successfully work in a team environment. Excellent oral and written communication skills.
• Good knowledge and application of GLP with the ability to train technical personnel.
• Efficient time management.
• Strong troubleshooting and analytical skills.
• Detail oriented and meticulous.
• Ability to work independently under time constraints.

Salary and Benefits:

• Frontage Laboratories offers a competitive compensation and generous benefits package including health and dental insurance, a 401(k) plan, health insurance, short and long-term insurance, life insurance etc.

Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to , , color, , , , , , status as a protected veteran, among other things, or status as a qualified individual with .