LC-MS Chemist - Metabolism

LAB Labcorp Early Development Laboratories Inc.; Madison (WI); On-site; USD 70,000 - 95,000; Full time

Benefits offered by this job

Medical

Dental

Vision

Life insurance

STD/LTD

401(k)

Paid Time Off (PTO)

Flexible Time Off (FTO)

Tuition Reimbursement

Employee Stock Purchase Plan

Job summary

Labcorp Early Development Laboratories Inc. in Madison, WI is seeking an LC-MS Chemist – Metabolism to perform method validation and data analysis for bioanalytical projects.

You will work on ADME/PK assays, operate triple quadrupole MS platforms, and collaborate with internal teams to deliver high-quality data to clients in a GLP/GCP-regulated environment.

Qualifications

• Bachelor's degree in Life Sciences, Chemistry, Biotechnology, or a related field.
• 1.5+ years of hands-on LC-MS/MS bioanalysis with MRM-based quantitation.
• 1.5+ years of ADME/PK assays including liver microsomal stability and permeability assays.
• 1.5+ years operating triple quadrupole MS platforms (e.g., Waters Xevo TQS, Agilent 6400 QQQ, SCIEX 5500/6500).

Responsibilities

• Organize and independently perform routine to moderate-level method validation activities in compliance with SOPs and regulatory guidelines (GLP/GCP).
• Execute advanced method validation tasks with guidance from a Lead Scientist.
• Apply intermediate data interpretation and analytical instrumentation skills to resolve problems with minimal assistance.
• Review reports, methods, protocols, and SOPs; maintain audit-ready study documentation.
• Communicate deviations and corrective actions to Lead Scientist/management promptly.
• Manage assigned project work and coordinate with team members to deliver high-quality data to clients on schedule.
• Collaborate with Bioanalytical site teams and external clients.
• Train and mentor less experienced staff.
• Contribute to process improvements and quality initiatives.
• Maintain a clean, safe laboratory environment.

Skills

LC-MS/MS

MRM quantitation

ADME/PK assays

Data interpretation

Education

Bachelor's degree in Life Sciences

Tools

MassLynx

MassHunter

Analyst

ELN

Orbitrap platforms

Job description

Labcorp is a global leader in laboratory services, providing the insights and answers that help healthcare providers, patients, researchers, pharmaceutical companies and health systems make confident decisions and improve outcomes. Through our unparalleled science, data, technology and laboratory network, we advance diagnostics, accelerate innovation and help address some of the world’s most important health challenges. As we shape the future of healthcare, we are leveraging advanced technologies, intelligent digital solutions and data-driven innovation across our operations to enhance how work gets done and deliver greater value to customers and patients. With our global scale and deep expertise, you’ll have the opportunity to do meaningful work, grow your career and make a real impact on people’s health around the world. Together, we’re improving health and improving lives. Labcorp is seeking an LC-MS Chemist – Metabolism to join our team in Madison, WI.

Work Schedule: Monday - Friday 8:00 am - 5:00 pm

Job Responsibilities

• Organize and independently perform routine to moderate-level method validation activities in compliance with SOPs and regulatory guidelines (GLP/GCP).
• Execute advanced method validation tasks with guidance from a Lead Scientist.
• Apply intermediate data interpretation and analytical instrumentation skills to resolve procedural and scientific problems with minimal assistance.
• Assist in the review of reports, methods, protocols, and SOPs; maintain complete and audit-ready study documentation.
• Communicate problems, deviations, and corrective actions to Lead Scientist and/or management in a timely manner.
• Manage assigned project work, coordinating activities with team members to deliver high-quality data to internal clients on schedule.
• Collaborate effectively with colleagues across the Bioanalytical site and support cross-functional communications with external clients.
• Train and mentor less experienced laboratory staff.
• Contribute to process improvement initiatives and participate in department-wide quality initiatives.
• Maintain a clean, safe, and organized laboratory environment.

Minimum Qualifications

• Bachelor's degree in Life Sciences, Chemistry, Biotechnology, or a related field.
• 1.5 or more years of hands-on experience with LC-MS/MS bioanalysis, including MRM-based quantitation and method execution.
• 1.5 or more years of experience with ADME/PK assays such as liver microsomal stability, permeability assays (e.g., MDCK-MDR1), and PK sample processing (plasma, tissue lysates).
• 1.5 or more years operating triple quadrupole mass spectrometer platforms (e.g., Waters Xevo TQS, Agilent 6400 QQQ, SCIEX 5500, and SCIEX 6500).

Preferred Qualifications

• Master's degree in Life Sciences, Chemistry, Biotechnology, or a related field.
• 1 or more years of exposure to CYP inhibition or Time-Dependent Inhibition (TDI) assays and drug-drug interaction (DDI) studies.
• 1 or more years of experience assisting in the development or optimization of new bioanalytical methods.

Additional Job Standards

• Proficiency with data acquisition and processing software (MassLynx, MassHunter, Analyst, or equivalent).
• Proficiency with ELN documentation, word processing, spreadsheet, and specialized analytical software.
• Strong attention to detail with demonstrated ability to generate reproducible, high-quality bioanalytical data.
• Familiarity with Orbitrap platforms or other high-resolution mass spectrometry systems.
• Knowledge of regulatory guidelines including FDA, EMA, and ICH bioanalytical method validation guidance.
• Experience working in a GLP/GCP-regulated environment (CRO or pharmaceutical/biotech industry).
• Excellent written and verbal communication skills.
• Proven ability to prioritize workloads and manage time effectively in a fast-paced laboratory environment.

Benefits

Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including:

• Medical
• Dental
• Vision
• Life
• STD/LTD
• 401(k)
• Paid Time Off (PTO)
• Flexible Time Off (FTO)
• Tuition Reimbursement
• Employee Stock Purchase Plan

Employees regularly scheduled to work less than 20 hours, Casual, Intern, and Temporary employees are only eligible to participate in the 401(k) Plan.

Labcorp is proud to be an Equal Opportunity Employer: Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. Additionally, all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law.

We believe in the power of science to change lives. Labcorp is a leading global life sciences company that provides vital information to help doctors, hospitals, pharmaceutical companies, researchers, and patients make clear and confident decisions. Through our unparalleled diagnostics and drug development capabilities, we provide insights and accelerate innovations to improve health and improve lives. Here, you can join our nearly 70,000 employees, serving clients in more than 100 countries, as we work together to transform approaches to patient care.