Senior Scientist, Medicinal and Structural Chemistry

Gilead; Foster City (CA); On-site; USD 169,000 - 220,000; Full time

Job summary

A leading company in the pharmaceutical industry seeks a Senior Scientist specializing in NMR Analytical Chemistry to enhance drug discovery efforts. The ideal candidate will bridge medicinal chemistry and NMR spectroscopy, contributing to the development of transformational medicines. Responsibilities include strategy development for NMR, instrument maintenance, and collaboration with cross-functional teams. Applicants should possess a strong background in NMR techniques and organic synthesis, with a Ph.D. or equivalent experience.

Benefits

Discretionary Annual Bonus

Stock-Based Long-Term Incentives

Paid Time Off

Medical Insurance

Dental Insurance

Vision Insurance

Life Insurance

Qualifications

• Ph.D. with 5 years, Master's with 10 years, or Bachelor's with 12 years in organic chemistry.
• Strong knowledge and experience in NMR spectroscopy.

Responsibilities

• Develop NMR strategy and enhance data analysis workflows.
• Maintain NMR facility for optimal performance.
• Provide training and support on NMR techniques.

Skills

NMR Spectroscopy

Medicinal Chemistry

Data Processing

Collaboration

Communication

Education

Ph.D. in Organic Chemistry

Master's in Organic Chemistry

Bachelor's in Organic Chemistry

Tools

Bruker NMR Instrumentation

Mnova NMR Software

Job description

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Senior Scientist, Medicinal and Structural Chemistry (NMR Analytical Chemist)

Location: Foster City, CA

This role represents an opportunity to maintain and further develop Gilead’s NMR facility and its impact on Gilead’s Small Molecule Drug Discovery organization toward achieving our goal of discovering transformational medicines. The ideal candidate will bridge the disciplines of medicinal chemistry and NMR spectroscopy through a deep knowledge of both fields as applied to small molecule drug discovery.

Responsibilities

• NMR Strategy: Further develop the strategy for NMR spectroscopy and enhance capabilities to include seamless data analysis workflows and quantitative NMR analysis.

• Instrument Maintenance: Responsible for maintaining existing NMR facility to ensure optimal performance and to support Gilead’s Medicinal Chemistry research organization.

• Structural Elucidation: Obtain and interpret multidimensional NMR data of small molecules and provide detailed reports and insights on chemical structures and properties.

• Medicinal Chemistry Expertise: Experience in prosecuting small molecule drug discovery programs and interpreting SAR. Expertise in hit to lead approaches including library expansion and parallel chemistry highly valued.

• Method Development: Develop and optimize traditional and novel NMR methods for various applications.

• Documentation: Maintain accurate and detailed records of all experiments, analyses, and results in accordance with industry standards and regulatory requirements.

• Training and Support: Provide training and technical support to junior staff and other team members on NMR techniques and instrument operation.

• Collaboration: Collaborate effectively with cross-functional teams.

Required Qualifications

• Ph.D. (with 5 years), Master's (+ 10 years) or Bachelor's (+ 12 years) in organic chemistry, or equivalent discipline with an emphasis in NMR techniques and multi-step organic synthesis.

• Strong knowledge and experience in NMR spectroscopy with proven applications in the pharmaceutical industry. Demonstrated ability to obtain and analyze NMR data to perform structure elucidation in a medicinal chemistry environment.

• Strong synthetic skills and a solid knowledge of modern organic synthesis techniques

• Strong data processing and analysis skills including coding language for data analysis and database management.

• Comprehensive knowledge of Bruker NMR instrumentation and software, methodology and Mnova NMR software.

• Excellent troubleshooting skills and ability to develop and optimize analytical methods.

• Effective written and verbal communication skills, with the ability to present findings clearly and concisely.

• Ability to work collaboratively in a team environment.

• High level of accuracy and attention to detail in all aspects of work.

Preferred Qualifications

• Experience with latest NMR techniques to elucidate interactions between small molecules and their drug targets.

• Experience with NMR based fragment screening methods.

• Experience with the use of liquid handlers for NMR sample preparation.

• Experience conducting multi-step organic synthesis.

• Recent experience conducting parallel or automated synthesis.

• Knowledge of DMPK and ADME principles.

The salary range for this position is: $169,320.00 - $219,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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