Senior Scientist II/Principal Scientist, Molecular Cloning Technologies

Flagship Pioneering; Cambridge (MA); On-site; USD 143,000 - 214,500; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Flagship Pioneering is seeking a Principal Scientist, Molecular Cloning Technologies in Cambridge, MA. This role involves leading the development and scaling of innovative RNA-based agricultural technologies, while defining strategies that support research and platform development.

Ideal candidates should possess a Ph.D. in Molecular Biology with over 12 years of experience in relevant fields and a track record of scientific leadership. A competitive salary range of $143,000 - $214,500 is offered, alongside comprehensive benefits including healthcare and retirement plans.

Qualifications

• Ph.D. in Molecular Biology with 12+ years of relevant experience.
• Demonstrated leadership in cloning technologies and platform development.
• Experience with high-throughput cloning workflows and laboratory automation.

Responsibilities

• Define and execute Terrana's cloning strategy.
• Own cloning function ensuring high-quality construct delivery.
• Develop and implement novel cloning technologies and workflows.

Skills

Molecular Cloning

DNA Assembly Technologies

Scientific Leadership

Laboratory Automation

Cross-Functional Collaboration

Education

Ph.D. in Molecular Biology or related field

Job description

Company Description

Founded through Flagship Pioneering’s venture creation engine, Terrana Biosciences is a cutting‑edge agricultural biotechnology company developing innovative RNA‑based products to address global agricultural challenges. We are committed to advancing sustainable farming solutions through precision technologies that ensure environmental safety and regulatory compliance.

The Role

Terrana Biosciences is building a new generation of RNA‑based technologies to transform agriculture. We are seeking an innovative and strategic Principal Scientist, Molecular Cloning Technologies to lead the vision, development, and scaling of cloning and construct generation capabilities across the company. As a scientific leader, you will define and drive cloning strategies that accelerate discovery, platform development, and product advancement. You will serve as the technical authority for molecular cloning technologies, develop novel high‑throughput workflows, and identify emerging approaches that strengthen Terrana’s RNA technology platform.

Key Responsibilities

• Define and execute the long‑term cloning strategy supporting Terrana’s research and platform development efforts.
• Own the cloning function and construct generation operations at Terrana, ensuring reliable, scalable, and cost‑effective delivery of high‑quality constructs supporting company pipeline activities.
• Conceive, develop, and implement novel cloning technologies, workflows, and automation solutions to enable rapid construct generation and testing.
• Drive continuous improvements in construct generation throughput, turnaround time, automation, quality, and unit economics while expanding organizational capacity.
• Lead innovation in high‑throughput DNA assembly, plasmid engineering, vector development, and viral engineering technologies.
• Evaluate emerging technologies and establish new capabilities that improve speed, scale, quality, and efficiency.
• Partner closely with Molecular Biology, Delivery, Discovery, Sequencing, and Bioinformatics teams to enable key research objectives and accelerate innovation.
• Mentor scientists and contribute to the development of technical talent and scientific culture across the organization.
• Drive external collaborations and represent Terrana’s cloning capabilities with scientific partners and collaborators.
• Communicate scientific strategy, findings, and recommendations to senior leadership.

Professional Experience & Qualifications

• Ph.D. in Molecular Biology, Synthetic Biology, Biotechnology, Biochemistry, Plant Biology, or a related field.
• Senior Scientist II: Ph.D. and 8‑11 years of relevant industry/postdoctoral experience with a demonstrated record of scientific leadership and innovation.
• Principal Scientist: Ph.D. and 12+ years of relevant industry/postdoctoral experience with a demonstrated record of scientific leadership and innovation.
• Demonstrated ability to balance scientific leadership with hands‑on laboratory execution in a fast‑paced, resource‑constrained environment.
• Deep expertise in molecular cloning, DNA assembly technologies, vector engineering, and construct design.
• Proven track record of developing and implementing novel technologies or platform capabilities.
• Experience leading complex, cross‑functional scientific initiatives from concept to execution.
• Experience developing, implementing, and scaling high‑throughput cloning workflows, laboratory automation solutions, and production operations.
• Strong communication, influence, and problem‑solving skills.
• Demonstrated creativity, scientific rigor, and an entrepreneurial mindset.

Preferred Qualifications

• Expertise in viral vector biology, host‑virus interactions, plant virology, or RNA virus engineering.
• Experience in agricultural biotechnology, plant biology, microbial engineering, or RNA‑based technologies.
• Familiarity with automated liquid handling platforms and laboratory information management systems (LIMS).
• Working knowledge of sequencing‑based construct verification and associated data analysis workflows.

Location

Cambridge, MA

Benefits

Salary Range: $143,000 – $214,500. Compensation may vary based on qualifications, skills, and experience. Terrana Biosciences, Inc. currently offers healthcare coverage, an annual incentive program, retirement benefits, and a broad range of additional benefits.

Equal Opportunity Employment

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.