Senior Scientist II/Principal Scientist, Molecular Cloning Technologies

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 143,000 - 215,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Terrana Biosciences is seeking a Principal Scientist, Molecular Cloning Technologies in Cambridge, MA to lead cloning strategy and construct generation. You will define long-term cloning platforms, drive scalable operations, and pioneer high-throughput workflows to accelerate RNA-based technology development.

The role requires a PhD with 12+ years of experience in molecular cloning and platform leadership, with strong collaboration skills and a track record of innovation.

Qualifications

• Ph.D. in molecular biology, synthetic biology, biotechnology, biochemistry, plant biology, or related field.

Responsibilities

• Define and execute the long-term cloning strategy supporting Terrana’s research and platform development efforts.
• Own the cloning function and construct generation operations at Terrana, ensuring reliable, scalable delivery of high-quality constructs.
• Conceive, develop, and implement novel cloning technologies, workflows, and automation solutions for rapid construct generation and testing.
• Drive continuous improvements in throughput, turnaround time, automation, quality, and unit economics while expanding capacity.
• Lead innovation in high-throughput DNA assembly, plasmid engineering, vector development, and viral engineering technologies.
• Evaluate emerging technologies and establish new capabilities to improve speed, scale, quality, and efficiency.
• Partner with Molecular Biology, Delivery, Discovery, Sequencing, and Bioinformatics teams to enable research objectives and accelerate innovation.
• Mentor scientists and contribute to development of technical talent and scientific culture.
• Drive external collaborations and represent Terrana’s cloning capabilities with scientific partners.
• Communicate scientific strategy, findings, and recommendations to senior leadership.

Skills

Molecular cloning

DNA assembly

Vector engineering

High-throughput workflows

Laboratory automation

Leadership

Scientific communication

Education

Ph.D. in Molecular Biology / Synthetic Biology / Biotechnology

Tools

Laboratory automation platforms

Job description

COMPANY DESCRIPTION

Founded through Flagship Pioneering’s venture creation engine, Terrana Biosciences is a cutting-edge agricultural biotechnology company developing innovative RNA-based products to address global agricultural challenges. We are committed to advancing sustainable farming solutions through precision technologies that ensure environmental safety and regulatory compliance.

THE ROLE

Terrana Biosciences is building a new generation of RNA-based technologies to transform agriculture. We areseekingan innovative and strategic Principal Scientist, Molecular Cloning Technologies to lead the vision, development, and scaling of cloning and construct generation capabilities across the company.

As a scientific leader, you will define and drive cloning strategies that accelerate discovery, platform development, and product advancement. You will serve as the technical authority for molecular cloning technologies, develop novel high-throughput workflows, and identify emerging approaches that strengthen Terrana’s RNA technology platform. This role requires a highly creative scientist who thrives at the intersection of technology innovation, scientific leadership, and operational excellence.

KEY RESPONSIBILITIES

• Define and execute the long-term cloning strategy supporting Terrana’s research and platform development efforts.
• Own the cloning function and construct generation operations at Terrana, ensuring reliable, scalable, and cost-effective delivery of high-quality constructs supporting company pipeline activities.
• Conceive, develop, and implement novel cloning technologies, workflows, and automation solutions to enable rapid construct generation and testing.
• Drive continuous improvements in construct generation throughput, turnaround time, automation, quality, and unit economics while expanding organizational capacity.
• Lead innovation in high-throughput DNA assembly, plasmid engineering, vector development, and viral engineering technologies.
• Evaluate emerging technologies and establish new capabilities that improve speed, scale, quality, and efficiency.
• Partner closely with Molecular Biology, Delivery, Discovery, Sequencing, and Bioinformatics teams to enable key research objectives and accelerate innovation.
• Mentor scientists and contribute to the development of technical talent and scientific culture across the organization.
• Drive external collaborations and represent Terrana’s cloning capabilities with scientific partners and collaborators.
• Communicate scientific strategy, findings, and recommendations to senior leadership.

PROFESSIONAL EXPERIENCE & QUALIFICATIONS

• Ph.D. in Molecular Biology, Synthetic Biology, Biotechnology, Biochemistry, Plant Biology, or related field.
  • Senior Scientist II: Ph.D. and 8-11 years of relevant industry and/or postdoctoral experience with a demonstrated record of scientific leadership and innovation.
  • Principal Scientist: Ph.D. and 12+ years of relevant industry and/or postdoctoral experience with a demonstrated record of scientific leadership and innovation.
• Demonstrated ability to balance scientific leadership with hands-on laboratory execution in a fast-paced, resource-constrained environment.
• Deep expertise in molecular cloning, DNA assembly technologies, vector engineering, and construct design.
• Proven track record of developing and implementing novel technologies or platform capabilities.
• Experience leading complex, cross-functional scientific initiatives from concept to execution.
• Experience developing, implementing, and scaling high-throughput cloning workflows, laboratory automation solutions, and production operations.
• Strong communication, influence, and problem-solving skills.
• Demonstrated creativity, scientific rigor, and an entrepreneurial mindset.

Preferred Qualifications

• Expertise in viral vector biology, host-virus interactions, plant virology, or RNA virus engineering.
• Experience in agricultural biotechnology, plant biology, microbial engineering, or RNA-based technologies.
• Familiarity with automated liquid handling platforms and laboratory information management systems (LIMS).
• Working knowledge of sequencing-based construct verification and associated data analysis workflows.

Location:

Cambridge, MA

ABOUT FLAGSHIP PIONEERING:

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship hasoriginatedmore than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

Recruitment & Staffing Agencies

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees isstrictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resumesubmittedby an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $143,000 - $214,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience.

• healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

Compensation and benefits information is based on Terrana Biosciences, Inc.’s good faith estimate as of the date of publication and may be modified in the future.

We are an equal opportunity employer

All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

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