Senior Scientist II, Ex Vivo Electrophysiology

Initial Therapeutics, Inc.; Cambridge (MA); On-site; USD 100,000 - 140,000; Full time

Job summary

A leading company in innovative medicines is seeking an experienced electrophysiologist for their Circuit Biology team focused on psychiatric drug discovery. This pivotal role emphasizes the execution of electrophysiological experiments to enhance understanding of circuit dysfunctions in psychiatric conditions. The ideal candidate will play a crucial role in research efforts, developing methodologies and guiding junior team members.

Benefits

Comprehensive medical/dental/vision insurance

Paid time off (vacation, holidays, sick leave)

Short-term incentive programs

Long-term incentive programs

Qualifications

• Experience in acute brain slice studies and intact circuitry.
• Demonstrated expertise in hypothesis-driven studies.
• Strong communication skills for cross-functional teams.

Responsibilities

• Execute and communicate original technical ideas in electrophysiology.
• Optimize in vitro and ex vivo experiments for psychiatric research.
• Train and guide junior scientists.

Skills

Whole-cell patch-clamp electrophysiology

Slice electrophysiology

Data interpretation

Education

PhD in neuroscience or related field

MS in neuroscience or related field

BS in neuroscience or related field

Job description

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Job Description

AbbVie is seeking an experienced and highly motivated electrophysiologist to join our Circuit Biology team within Discovery Psychiatry. This pivotal role involvesfacilitating in vitro and ex vivo electrophysiological insights of circuit biology to drive our understanding of synaptic and circuit dysfunction in psychiatric disorders and treatment. This is an excellent opportunity to work at the forefront of psychiatry drug discovery research, contributing to target validation and compound profiling studies within a dynamic and collaborative team.

Key Responsibilities

• Independently conceive, execute, and communicate original technical ideas and novel multi-disciplinary research that achieves project and area goals
• Drive internal electrophysiology efforts by developing and optimizing disease-relevant in vitro andex-vivo experiments to investigate synaptic and circuit function
• Develop and maintain slice electrophysiology technology, methodology, and utility in psychiatric drug discovery
• Generate, through lab-based activities, slice electrophysiology data to support projects
• Ensure alignment of electrophysiology efforts with the broader goals of cross-functional teams
• Present findings to internal teams and external collaborators or conferences
• Contribute to strategic decision-making in psychiatry drug discovery
• Provide scientific guidance and training to junior scientists and research associates
• Serve as a lead scientist on projects and contribute scientific insights across multiple other project teams

Qualifications

• PhD, MS, or BS in neuroscience, or related field, with typically 4+ (PhD), 10+ (MS) or 12+ (BS) years of experience
• Extensive experience in whole-cell patch-clamp electrophysiology in acute brain slices, in vitro and ex vivo slice electrophysiology
• Extensive experience using slice electrophysiology to study intact circuitry from striatal, cortical and hippocampal networks
• Demonstrated expertise in the design and execution of hypothesis-driven studies related to synaptic and circuit function
• Ability to process and interpret large datasets using appropriate software tools
• Strong ability to work in cross-functional teams and effectively communicate scientific findings

Desired Qualifications

• Previous industry experience within early discovery, preferably within psychiatry research
• Expertise in ion channel drug discovery
• Recognized and sought out as an expert in field or discipline
• Track record of impactful publications

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible to participate in our short-term incentiveprograms.

• This job is eligible to participate in our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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