Senior Scientist II, Early Analytical Peptide Development, Synthetic Molecules

AbbVie; North Chicago (IL); On-site; USD 110,000 - 140,000; Full time

Benefits offered by this job

Health insurance

401(k) plan

Paid time off

Long-term incentive programs

Job summary

AbbVie seeks a Senior Scientist II to independently conceive and execute novel scientific research in analytical development, focusing on transitioning NCEs and synthetic peptides from discovery to development. You will collaborate across PCS, Process Chemistry, QA, and CMC-Regulatory affairs to deliver robust analytical capabilities.

The role requires strong peptide development experience, expertise in chromatographic analysis (HPLC/GC) and mass spectrometry, and the ability to work in a

Qualifications

• Doctoral degree or equivalent with strong analytical focus and experience in peptide development.
• Experience with HPLC and method development; understanding of spectroscopic techniques related to peptides.
• Ability to discuss organic chemistry topics in analytical R&D with cross-functional partners.

Responsibilities

• Lead and support peptide product development from an analytical perspective.
• Apply advanced analytics to drive the pipeline and research initiatives.
• Develop analyses for drugs substances, impurities, and impurity profiling.
• Independently perform lab research and method development in a fast-paced team.
• Design follow-on experiments and interpret multidisciplinary data.
• Process and visualize data to inform project decisions.
• Implement analytical control strategies to advance drug discovery candidates.

Skills

Analytical Chemistry

Peptide development

HPLC

Mass Spectrometry

Data handling

Interdisciplinary collaboration

Communication skills

Analytical method development

Education

Ph.D. in Analytical Chemistry

Tools

HPLC

GC

Mass Spectrometry

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

For the Senior Scientist II position, we are seeking a highly motivated candidate who can conceive, implement and execute novel scientific research and development, independently develop, optimize new methods and techniques to generate reliable and reproducible data in a timely manner and demonstrate broad versatile technical expertise. They will support early phase development of New Chemical Entities (NCEs), particularly synthetic peptides, in both the preclinical- and clinical-development space and collaborate within the global Analytical R&D organization and with R&D cross-functional partners such as Pre-Clinical Safety (PCS), Process Chemistry, Process Engineering, Drug Product Development (DPD), Quality Assurance (QA), and CMC-Regulatory Affairs.

This position will focus primarily on transitioning NCEs from Discovery into Development Sciences and the individual will independently serve as an Analytical Research and Development representative in a highly cross-functional team, which includes Discovery, Process Chemistry, Quantitative and Translational ADME Sciences (QTAS), Safety Pharmacology, Pre-Clinical Safety (PCS), and Molecular Profiling and Drug Delivery (MPDD). Candidates should be comfortable discussing organic chemistry topics relevant to analytical chemistry, such as stereoisomers, common functional groups, and pKa values. Experience with peptide development is required and chromatographic analysis (such as HPLC or GC) and Mass Spectrometry is highly preferred.

Responsibilities

• Responsible for efficiently leading and supporting new peptide product development, from an analytical perspective, while working with cross-functional areas to advance projects through the development pipeline.


• Support new peptide product development with advanced analytics to drive the pipeline and impactful research initiatives.


• Utilize understanding of a range of analytical techniques to conduct research and development studies related to synthetic-molecule drug substances, impurities, and impurity profiling.


• Highly autonomous and productive in performing laboratory research and/or method development, requiring only minimal direction from or interaction with supervisor.


• Initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.


• Formulate conclusions and design follow-on experiments based on multidisciplinary data.


• Process, interpret, and visualize data to facilitate project team decisions.


• Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.


• Responsible for method development, testing procedures, and implementation of analytical control strategies to help the advancement of drug discovery candidates.


• Raises the bar and is never satisfied with the status quo.

Qualifications

• Bachelors, Masters, or Ph.D. in Analytical Chemistry or Pharmaceutical Sciences (with strong Analytical Focus) typically with minimum 12 (BS), 10 (MS), or 4 (Ph.D.) years related industry experience.


• Strong technical background in peptide development with excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.


• Demonstrated experience with HPLC analysis and method development preferred along with expertise and fundamental understanding of spectroscopic techniques as they relate to peptide development and small molecules.


• Comfortable discussing organic chemistry topics within analytical R&D and with partner functions. Hands-on experience with synthetic organic chemistry preferred.


• Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.


• Experience in the use of computerized data handling systems.


• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.


• Practical knowledge of organic structure, functional groups, chemistry, and modern spectroscopic techniques as applied to small-molecule analytical analysis.


• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.


• Learns fast, grasps the \"essence\" and can change course quickly where indicated.


• Creates a learning environment, open to suggestions and experimentation for improvement.


• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.


• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.


• This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html