Senior Scientist II, Computational Chemistry-Drug Discovery

Exelixis; Alameda (CA); On-site; USD 149,000 - 188,000; Full time

Benefits offered by this job

401(k) plan with company contributions

Comprehensive medical, dental, and/or视

Job summary

Exelixis is seeking a Senior Scientist II in Computational Chemistry to advance drug discovery through physics-based modeling, cheminformatics, and data-driven workflows. You will integrate molecular dynamics, docking, and ML to generate testable design hypotheses and prioritize compounds in collaboration with medicinal chemists and biologists.

The role emphasizes developing reliable computational pipelines, applying validation methods, and communicating results to cross-functional teams in a

Qualifications

• PhD/MS/BS with extensive experience in computational chemistry or cheminformatics.

Responsibilities

• Apply ligand- and structure-based computational methods to support small-molecule discovery programs.

Skills

Molecular modeling

Python

Cheminformatics

Machine learning

Structure-based design

Education

PhD in Computational Chemistry or related

MS in related discipline with industry experience

BS in related discipline with extensive experience

Equivalent education/experience

Tools

RDKit

OpenMM

GROMACS

AMBER

Job description

Exelixis is seeking a Senior Scientist II in Computational Chemistry to advance drug discovery through physics-based modeling, cheminformatics, and data-driven workflows. You will integrate molecular dynamics, docking, and ML to generate testable design hypotheses and prioritize compounds in collaboration with medicinal chemists and biologists.

The role emphasizes developing reliable computational pipelines, applying validation methods, and communicating results to cross-functional teams in a