Senior Scientist II, Biophysics and Protein Sciences

Scorpion Therapeutics; California (MO); On-site; USD 170,000 - 212,000; Full time

Job summary

Scorpion Therapeutics in Redwood City, CA is seeking a Biophysicist specializing in protein characterization to support oncology drug discovery with a focus on RAS-addicted cancers. You will lead orthogonal biophysical techniques (DSF, SEC-MALS, ITC, SPR) to validate targets, confirm hits, and elucidate protein interactions, including weak or transient ones relevant to molecular glue platforms.

Collaborating closely with Structural Biology, Medicinal Chemistry, and Discovery Biology teams, you

Qualifications

• PhD in Biophysics or related field required.
• 8+ years in industry drug discovery with hands‑on protein biochemistry/biophysics experience.
• Strong data integration skills across disciplines.

Responsibilities

• Lead orthogonal biophysical techniques (e.g., DSF, SEC-MALS, ITC, SPR) to validate targets, confirm hits, and elucidate protein interactions.
• Collaborate with Structural Biology, Medicinal Chemistry, and Discovery Biology teams to inform project decisions and optimize workflows.

Skills

Biophysics

Biochemistry

Structural Biology

Drug Discovery

Data Integration

Education

PhD in Biophysics/Biochemistry/Structural Biology

Tools

DSF

SEC-MALS

ITC

SPR

SAXS

NMR

Job description

Role

Biophysicist specializing in protein characterization to support drug discovery in oncology, focusing on RAS-addicted cancers.

Responsibilities

• lead the application of orthogonal biophysical techniques (e.g., DSF, SEC-MALS, ITC, SPR) to validate targets, confirm hits, and elucidate protein interactions, especially weak or transient ones relevant to molecular glue platforms.
• Collaborate closely with Structural Biology, Medicinal Chemistry, and Discovery Biology teams to inform project decisions, develop robust assays, and optimize workflows for protein quality assessment.

Requirements

• Ph.D. in Biophysics, Biochemistry, Structural Biology, or related field; 8+ years in industry drug discovery; extensive hands‑on experience with protein biochemistry and biophysical methods; strong data integration skills across disciplines.

Preferred

• experience with molecular glues, higher-order biophysics (e.g., SAXS, NMR), and establishing new biophysical workflows; proven track record in mechanistic problem solving and reducing technical risks.

High Value

• oncology (RAS-addicted cancers)
• protein-protein interactions
• drug discovery
• biophysical assay development
• orthogonal validation strategies
• regenerative complex characterization

Work Setup

full-time onsite in Redwood City, CA; salary range $170,000-$212,000.