Principal Scientist, Biophysicist

Scorpion Therapeutics; South Dakota; On-site; USD 109,000 - 222,000; Full time

Benefits offered by this job

Health benefits

Life/disability insurance

401(k) with company match

Time off package

Job summary

Scorpion Therapeutics located in La Jolla, CA is seeking a Principal Scientist I/II to design and optimize biophysical assays for small molecules. The role involves leading experiments, collaborating across teams, and presenting data to stakeholders.

The candidate will drive automation initiatives, manage multiple projects, and contribute to high-impact publications. Requires a PhD with 2+ years in industry and strong troubleshooting skills.

Qualifications

• Ph.D. in Biophysics, Biochemistry, or Bioengineering with 2+ years in drug discovery.
• Deep expertise in designing, validating, executing, and troubleshooting biophysical assays.
• Ability to manage multiple projects independently and adapt to evolving priorities.
• Ability to innovate; recommend and bring in new technologies.
• Strong analytical, troubleshooting, and problem-solving skills.
• Excellent communication and teamwork abilities.

Responsibilities

• Design, develop, and optimize biophysical assays (SPR, BLI) for small molecules.
• Execute routine assays to define structure-activity relationships.
• Implement and manage automation to enhance throughput and data quality.
• Collaborate with cross-functional teams to integrate new technologies and workflows.
• Analyze, interpret, and present scientific data to stakeholders.
• Maintain detailed laboratory records; contribute to reports and publications.

Job description

Internal Job Title: Principal Scientist I/Principal Scientist II
Position Location: Onsite, La Jolla, CA

Key Responsibilities:

• Design, develop, and optimize biophysical assays (e.g., SPR, BLI) for characterization of small molecules.
• Execute routine assays for defining structure-activity relationships.
• Implement and manage automation solutions to enhance assay throughput and data quality.
• Collaborate with cross-functional teams to integrate new technologies and workflows into ongoing research projects.
• Analyze, interpret, and present scientific data to internal and external stakeholders.
• Maintain detailed laboratory records; contribute to research reports and publications; represent the team through internal presentations.

Essential Requirements:

• Ph.D. (post-doc preferred) in a relevant scientific discipline (e.g., Biophysics, Biochemistry, Bioengineering, or related), with 2+ years of industrial experience in drug discovery.
• Deep expertise in designing, validating, executing, and troubleshooting biophysical assays.
• Ability to manage multiple projects independently and adapt to evolving priorities.
• Ability to innovate; recommend and bring in new technologies.
• Strong analytical, troubleshooting, and problem-solving skills.
• Excellent communication and teamwork abilities.

Desirable Requirements:

• Experience integrating novel/emerging technologies into high-throughput screening workflows.
• Familiarity with data analysis software and electronic laboratory management systems.
• Hands-on experience with laboratory automation platforms and liquid handling systems.

Compensation & Benefits (as stated):

• Salary range: Principal Scientist I $108,500–$201,500; Principal Scientist II $119,700–$222,300 (final based on skills/experience; may change).
• Performance-based cash incentive; annual equity awards may be available.
• Comprehensive benefits including health, life/disability, 401(k) with company match, and time off package.