Senior Scientist II, Biologics Analytical R&D

Califesciences; South San Francisco (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

A leading company in innovative biotherapeutics is seeking a Senior Scientist II in South San Francisco. The role involves analytical development for novel biotherapeutics, utilizing expertise in protein chemistry and chromatography, with responsibilities in method development and regulatory compliance. Ideal candidates will have extensive experience and a strong collaborative attitude.

Benefits

Comprehensive medical/dental/vision insurance

401(k) with company match

Paid time off

Short-term and long-term incentive programs

Qualifications

• Advanced degree required depending on experience level (Bachelor's, Master's, PhD).
• Experience in CMC analytical development of biotherapeutic proteins is desirable.
• Ability to thrive in a collaborative lab environment.

Responsibilities

• Develop capillary electrophoresis and HPLC methods for characterizing biotherapeutic proteins.
• Engage in regulatory submission planning and authoring.
• Provide technical support for QC testing in GMP laboratories.

Skills

Protein chemistry

Biochemistry

Chromatography

Capillary electrophoresis

Technical/scientific achievement

Quality control (QC)

GMP experience

Strong written communication

Strong verbal communication

Education

Bachelor's Degree or equivalent with 12 years of experience

Master's Degree or equivalent with 10 years of experience

PhD with 4 years of experience

Tools

HPLC/UPLC

Job description

ICompany Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

AbbVie's Biologics CMC Analytical Research and Development Group in South San Francisco has an exciting opportunity for a Senior Scientist II to join a dynamic team of scientists responsible for all aspects of CMC analytical development required to move biologic candidates from discovery into and through clinical studies.

In this lab-based role, you will utilize your knowledge of protein chemistry and expertise in chromatography and capillary electrophoresis to contribute to development of AbbVie's growing pipeline of clinical stage biotherapeutics, which include novel bispecific and multispecific constructs, antibody-drug conjugates, and monoclonal antibodies. You will characterize and investigate attributes of biologic drug candidates to provide product and process understanding, as well as develop innovative analytical methods that provide deeper insights into protein biotherapeutics across the development spectrum from candidate liability screening to process development to clinical development.

Key Responsibilities Include:

• Independently develop state of the art capillary electrophoresis and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities.
• Characterize post-translational modifications and structure-activity relationships of products under development.
• Develop innovative approaches to solve difficult analytical challenges.
• Represent the Biologics CMC Analytical Research and Development Group as a subject matter expert on cross functional project teams.
• Develop, qualify/validate, and transfer fit-for-purpose QC release and stability methods.
• Provide technical support and oversight for QC testing occurring at internal and external GMP laboratories.
• Plan and author characterization, comparability, and quality sections of regulatory submissions (INDs/CTDs).
• Engage and influence the broader scientific community through publications and poster and oral presentations at industry conferences.

Qualifications

• Bachelor's Degree or equivalent education and 12 years of experience, Master's Degree or equivalent education and 10 years of experience, PhD and 4 years of experience. Applicants with less experience will be observed as well; leveling will be commensurate to experience level.
• Must possess a solid understanding of protein chemistry and biochemistry, particularly as it relates to biotherapeutic protein drug development.
• Demonstrated proficiency in developing and performing protein capillary electrophoresis, HPLC/UPLC, and other separation methods as they apply to protein characterization.
• Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is desired.
• Prior example(s) of technical/scientific achievement and innovation in advanced analytics (e.g., multi-dimensional liquid chromatography, novel separation techniques) is desirable.
• Quality control and/or GMP experience is beneficial.
• Must have strong written and verbal communications skills.
• This position is a lab-based role. To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment and be able to manage multiple concurrent projects with a high degree of independence.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• This is an on-site opportunity located in South San Francisco.
• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
• This job is eligible to participate in our long-term incentive programs

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.htmlI