Senior Scientist I/II, Biologics Analytical R&D

AbbVie Inc; South San Francisco (CA); On-site; USD 106,000 - 203,000; Full time

Job summary

AbbVie is seeking a Senior Scientist II in South San Francisco to lead CMC analytical development for biologic drug candidates. The role focuses on developing innovative methods for characterizing biotherapeutic proteins, contributing to clinical stage projects, and representing the group on cross-functional teams. Candidates should hold an advanced degree and have extensive analytical experience in a lab-based environment.

Benefits

Comprehensive benefits package

Paid time off

401(k) plan

Short-term incentive programs

Long-term incentive programs

Qualifications

• 12 years experience for Bachelor's, 10 years for Master's, and 4 years for PhD.
• Solid understanding of biotherapeutic protein drug development required.
• Demonstrated proficiency in analytical method development.

Responsibilities

• Develop and qualify analytical methods for biotherapeutics.
• Characterize post-translational modifications.
• Provide oversight for QC testing.

Skills

Protein chemistry

Chromatography

Capillary electrophoresis

Technical communication

Education

Bachelor’s Degree

Master’s Degree

PhD

Tools

HPLC/UPLC

Job description

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Job Description

AbbVie’s Biologics CMC Analytical Research and Development Group in South San Francisco has an exciting opportunity for a Senior Scientist II to join a dynamic team of scientists responsible for all aspects of CMC analytical development required to move biologic candidates from discovery into and through clinical studies.

In this lab-based role, you will utilize your knowledge of protein chemistry and expertise in chromatography and capillary electrophoresis to contribute to development of AbbVie’s growing pipeline of clinical stage biotherapeutics, which include novel bispecific and multispecific constructs, antibody-drug conjugates, and monoclonal antibodies. You will characterize and investigate attributes of biologic drug candidates to provide product and process understanding, as well as develop innovative analytical methods that provide deeper insights into protein biotherapeutics across the development spectrum from candidate liability screening to process development to clinical development.

Key Responsibilities Include:

• Independently develop state of the art capillary electrophoresis and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities.
• Characterize post-translational modifications and structure-activity relationships of products under development.
• Develop innovative approaches to solve difficult analytical challenges.
• Represent the Biologics CMC Analytical Research and Development Group as a subject matter expert on cross functional project teams.
• Develop, qualify/validate, and transfer fit-for-purpose QC release and stability methods.
• Provide technical support and oversight for QC testing occurring at internal and external GMP laboratories.
• Plan and author characterization, comparability, and quality sections of regulatory submissions (INDs/CTDs).
• Engage and influence the broader scientific community through publications and poster and oral presentations at industry conferences.

Qualifications

• Bachelor’s Degree or equivalent education and 12 years of experience, Master’s Degree or equivalent education and 10 years of experience, PhD and 4 years of experience. Applicants with less experience will be observed as well; leveling will be commensurate to experience level.
• Must possess a solid understanding of protein chemistry and biochemistry, particularly as it relates to biotherapeutic protein drug development.
• Demonstrated proficiency in developing and performing protein capillary electrophoresis, HPLC/UPLC, and other separation methods as they apply to protein characterization.
• Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is desired.
• Prior example(s) of technical/scientific achievement and innovation in advanced analytics (e.g., multi-dimensional liquid chromatography, novel separation techniques) is desirable.
• Quality control and/or GMP experience is beneficial.
• Must have strong written and verbal communications skills.
• This position is a lab-based role. To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment and be able to manage multiple concurrent projects with a high degree of independence.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• This is an on-site opportunity located in South San Francisco.
• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture. Salary: $106,500 - $202,500
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible to participate in our short-term incentiveprograms.
• This job is eligible to participate in our long-term incentiveprograms

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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https://www.abbvie.com/join-us/reasonable-accommodations.html