Senior Scientist II

AbbVie Inc.; Worcester (MA); Sur place; USD 90 000 - 140 000; Plein temps

Avantages offerts par ce poste

Paid time off

Medical/dental/vision insurance

401(k)

Résumé du poste

AbbVie in Worcester, MA is seeking a Senior Scientist I/II to advance analytical development of biologics, developing and transferring methods (HPLC, capillary electrophoresis) for CMC. You will mentor teammates and contribute to regulatory submissions.

Ideal candidates hold a PhD or MS with extensive Biochemistry/Analytical Chemistry experience; strong writing and communication; opportunities to publish and present at conferences.

Qualifications

• PhD or MS with substantial biochemistry/CMC experience.
• Experience in development, qualification and transfer of analytical methods.
• Strong written and verbal communication skills for reports and regulatory submissions.

Responsabilités

• Develop and apply capillary electrophoresis and HPLC methods for biologic process development.
• Qualify and transfer in-process control methods to QC.
• Provide technical support to QC testing at GMP labs.
• Lead analytical innovations and publish findings.

Connaissances

Analytical method development

HPLC

Capillary electrophoresis

Mentoring

Scientific communication

Formation

PhD in Biochemistry/Analytical Chemistry/Pharmaceutical Science

MS with 10+ years of industry experience

Outils

HPLC

CE

icIEF

SoloVPE

Description du poste

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

AbbVie is searching for a highly motivated individual to fill a Senior Scientist I/II position in the Analytical Development Department at AbbVie Bioresearch Center in Worcester MA. The Analytical Development Department is responsible for development, qualification and execution of analytical methods and characterization studies to provide product and process understanding for development of AbbVie biopharmaceutical pipeline from discovery through commercial stages.

Analytical Development is seeking a highly experienced, motivated and team-oriented individual for an important role supporting development of AbbVie’s biologic pipeline of preclinical and clinical products. The successful candidate will be a member of the Process Analytics team responsible for development and execution of various separation methods (HPLC, CE, icIEF, etc.) and other analytical methods (small scale purification, SoloVPE, etc.) to support the CMC development of AbbVie early phase products and processes throughout the drug development lifecycle.

Key Responsibilities:

• Independently develop and apply capillary electrophoresis, and HPLC methods separation as well as other analytical methods to enable biological process development
• Develop, qualify, and transfer fit-for-purpose in-process control methods to QC.
• Provide technical support to QC testing occurring at internal and external GMP testing laboratories.
• Demonstrate the ability to resolve key project hurdles and assumptions by effectively utilizing available information and technical expertise.
• Publish research in peer-reviewed journals and present work at scientific conferences.
• Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program.
• Seize opportunities to pursue project relevant leads that are in line with the group’s strategy
• Maintain a high level of productivity in the lab.
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable.
• May mentor/supervise a team of one or more and guide and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals.
• Represent analytical function in the CMC program team; represent the Analytical Development Group as a subject matter expert on cross functional teams. Lead the development of analytical control strategy for biologic programs
• Plan and author internal technical reports as well as relevant CMC sections of regulatory submissions (INDs/CTDs).
• Identify and lead analytical innovations to further scientific capability of the group.
• PhD Degree and 0-4+ years or MS with 10+ years of experience within Biochemistry, Chemical Engineering, Analytical Chemistry, Pharmaceutical Science (or related discipline) in industry or academia.
• Possess thorough theoretical and practical understanding of own scientific discipline.
• Effective writer and communicator of research or other regulatory materials.
• Must have strong written and verbal communications skills.

Preferred Qualifications:

• Ability to work effectively cross-functionally in anticipating and responding to overall program development needs
• Demonstrated record of independent thought, creativity and scientific accomplishment
• Self-motivated with the ability to act with urgency and passion
• Ability to make thoughtful, integrated, timely and meaningful recommendations and/or decision and take corresponding actions
• Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is a plus.

Key Leadership Competencies:

• Delivers business results while also positioning AbbVie for long-term success
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html