Senior Scientist I, Pharmacology

Blueprint Medicines; Buffalo (MA, NY); On-site; USD 90,000 - 150,000; Full time

Job summary

Join a dynamic team at a pioneering biopharmaceutical company where your expertise in in-vivo pharmacology will drive innovative drug development. As a Senior Scientist, you'll lead research strategies, collaborate across functions, and contribute to the advancement of life-changing medicines. This role is perfect for a passionate scientist ready to make a significant impact in the field of pharmacology, working on groundbreaking projects that aim to improve patient outcomes. If you're looking for an engaging and collaborative environment, this opportunity is your chance to transform hope into reality.

Benefits

Health insurance

Retirement plan

Flexible working hours

Professional development

Paid time off

Wellness programs

Employee assistance program

Qualifications

• PhD in pharmacology or related field with industry experience.
• Strong foundation in pharmacological principles and in-vivo studies.
• Ability to lead effectively in a matrixed drug discovery environment.

Responsibilities

• Design and perform in vivo pharmacology studies for drug candidates.
• Collaborate with discovery teams and manage in vivo research.
• Analyze and report in vivo and ex vivo data regularly.

Skills

In-vivo pharmacology

Pharmacological principles

Flow cytometry

ELISA

Western blot

Quantitative RT-PCR

Project management

Creative problem solving

Education

PhD in pharmacology, biology, or related discipline

MS degree with 8+ years of experience

Tools

CRO management

In vivo disease models

Multiparameter flow cytometry

Job description

How will your role help us transform hope into reality?

The Senior Scientist, Pharmacology will lead efforts within discovery projects to develop and implement in-vivo pharmacology strategies that contribute to demonstration of proof of concept and inform the identification, selection, and characterization of drug candidates. You will be accountable for the characterization of all aspects of in-vivo pharmacology in rodent and (when appropriate) higher species models of disease. You will serve as the Pharmacology representative on discovery core teams and will be expected to collaborate closely with partner functions (e.g. Biology, Medicinal Chemistry, Laboratory Animal Resources, Pharmaceutical Sciences, Translational Medicine, DMPK, Drug Safety) to impact experiment/study design and facilitate line of sight from Discovery to IND. This opportunity is highly collaborative, team-facing, and strategic, and you will also be responsible for designing and performing hands-on in-vivo studies conducted in the internal vivarium[RR1] . The successful applicant will be an outstanding scientist capable of independently leading in-vivo research efforts whether in-house or outsourced, and supporting collaborations with KOLs in specific areas of interest to the company.

What will you do?

• Provide pharmacology expertise to discovery programs: design, perform, interpret in vivo pharmacology studies to evaluate the activities of small molecule drug candidates, investigate their mechanisms of action, and explore novel therapeutic hypotheses


• Work seamlessly with discovery teams, the head of Laboratory Animal Resources, and the In Vivo Pharmacology Team to plan, perform, resource, and prioritize in-house and outsourced pharmacology activities


• Manage and perform hands-on in vivo pharmacology research in-house in a matrixed environment, as well as support studies being performed through an extensive network of CROs


• Perform ex vivo cell and tissue work, including but not limited to flow cytometry, ELISA, western blot, and quantitative RT-PCR


• Regularly analyze, document, and report in vivo and ex vivo data


• Regularly participate in project team meetings and present in vivo pharmacology results


• Manage in vivo pharmacology studies being performed at CROs


• Think strategically about drug development and drive innovative solutions to key challenges across the organization


• Responsible for In Vivo Pharmacology contributions to INDs , including preparation of nonclinical study reports


• Perform other responsibilities as assigned

What minimum qualifications do we require?

• PhD in pharmacology, biology, immunology or related discipline with 4+ years of additional industry experience in in-vivo pharmacology or a MS degree with 8+ years of demonstrated ability leading in-vivo pharmacology projects

What additional qualifications will make you a stronger candidate?

• Strong foundation in pharmacological principles


• Hands-on experience designing and performing in-vivo disease models in rodents, including tumor models or inflammatory disease models to assess efficacy and PK/PD is essential


• Hands-on experience with various routes of administration in rodents is essential


• Hands-on experience with rodent tissue collection and ex vivo processing techniques


• Experience in determining PK/PD to activity relationships in vivo in diseased and surrogate tissues


• Strong attention to detail and exceptional interpersonal, organizational, and communication skills


• Demonstrated ability to successfully influence internal and external cross-functional teams by exhibiting creative problem solving, clear decision-making, and accountability


• Experience with drug modalities beyond small molecules.


• Experience leading pharmacology aspects of projects at all stages of discovery and experience with preparation of nonclinical study reports is a plus


• Prior experience performing and interpreting in vivo/ex vivo immunological assays,


• Hands-on experience with multiparameter flow cytometry


• Ability to work effectively with project leads and project teams that have diverse personalities and styles


• Ability to lead effectively in a matrixed drug discovery environment


• Experience identifying, selecting, and overseeing the work of external CROs, consultants and partners


• Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators - the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equal Employment Opportunity

At Blueprint Medicines, we foster an environment of fair treatment and full participation for all of our employees as we navigate complex challenges in pursuing our mission to improve the lives of patients. We celebrate our unique differences and varied career and life experiences so that we can sustain our diverse culture and ensure everyone feels accepted. We are committed to non-discrimination, equal employment opportunity, as well as an inclusive recruitment process. We consider all qualified applicants based on merit and without regard to race, color, sex, gender identity, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable federal or state law.

We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out [e-mail]. We are also an E-Verify Employer. For more information, please see our EEO Policy Statement, the E-Verify Participation Poster, the Right to Work Poster, and/or the EEO Know Your Rights Poster.

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

#LI-Hybrid #LI-AQ1