Senior Scientist I, Mass Spectrometry

BioSpace; North Chicago (IL); On-site; USD 80,000 - 120,000; Full time

Job summary

A leading company in the pharmaceutical industry is seeking a Senior Scientist I specializing in Mass Spectrometry. The role involves developing analytical methods for peptides and oligonucleotides, collaborating with cross-functional teams, and supporting drug development. Ideal candidates will have a strong background in analytical chemistry and mass spectrometry, along with excellent communication skills.

Qualifications

• 10+ years for BS, 8+ for MS, or 0-2 for Ph.D. in industry experience.
• Extensive experience in mass spectrometry for peptides and proteins.

Responsibilities

• Utilize mass spectrometry techniques to characterize drug products.
• Develop and implement analytical methods for pharmaceuticals.

Skills

Analytical Chemistry

Problem Solving

Communication

Education

Bachelors in Chemistry

Masters in Biochemistry

Ph.D. in related field

Tools

Mass Spectrometry

LC-MS

Data Handling Systems

Job description

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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, and eye care, as well as products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn, and TikTok.

Job Description

The Analytical Research & Development team is seeking a talented, highly motivated candidate with experience in the characterization of peptide and oligonucleotide biomolecules. This is a laboratory-based role, responsible for designing, developing, and implementing analytical methods for the characterization of peptides and oligonucleotides, with an emphasis on mass spectrometry-based methods. The candidate should possess an understanding of their core discipline and use that expertise to support early phase development of drug substance and drug product, collaborating with cross-functional partners such as Pre-Clinical Safety, Process Chemistry, Process Engineering, Drug Product Development, Quality Assurance, and CMC-Regulatory.

Responsibilities

1. Utilize cutting-edge mass spectrometry techniques, including high-resolution MS, MS/MS, ion mobility-MS, and 2DLC-MS, to characterize small molecule, peptide, and oligonucleotide drug products, active pharmaceutical ingredients, intermediates, starting materials, and impurities.
2. Identify, develop, and implement novel analytical methods for the characterization of peptide and oligonucleotide pharmaceuticals, focusing on LC-MS and biophysical characterization to support discovery and development pipelines.
3. Lead structure elucidation efforts and collaborate with cross-functional teams to advance programs through development stages.
4. Support new product development with method development, validation, technical transfer, and regulatory data generation.
5. Perform laboratory research or method development autonomously with minimal supervision.
6. Formulate conclusions and design follow-up experiments based on multidisciplinary data.
7. Initiate new investigations that are scientifically meaningful and applicable to R&D programs.
8. Communicate and collaborate effectively across departments.
9. Demonstrate scientific initiative and maintain high productivity in the lab.

Qualifications

1. Bachelors, Masters, or Ph.D. in Chemistry, Biochemistry, or related field, with 10+ (BS), 8+ (MS), or 0-2 (Ph.D.) years of industry experience.
2. Extensive experience in mass spectrometry experiments for peptides, proteins, or oligonucleotides, with strong instrument knowledge.
3. Strong analytical chemistry background, problem-solving skills, and ability to develop and troubleshoot methods independently.
4. Knowledge of organic structure, chemistry, biochemistry, and spectroscopic techniques.
5. Peptide synthesis experience is a plus.
6. Self-motivated, detail-oriented, able to work in a fast-paced environment.
7. Experience with data handling systems.
8. Excellent communication skills for interacting with interdisciplinary teams.

Additional Information

Details about compensation, benefits, and equal opportunity employment policies are included, with links to relevant pages for more information.