Senior Scientist I/II, Pharmacology and Translational Science

Artiva Biotherapeutics Inc.; San Diego (CA); On-site; USD 149,000 - 183,000; Full time

Benefits offered by this job

Medical, Dental, and Vision

Group Life Insurance

Long Term Disability

401(k) Retirement Plan

Employee Assistance Program

Flexible Spending Account

Paid Time Off

Company paid holidays

Bonus.ly rewards

Job summary

Artiva Biotherapeutics is seeking a Senior Scientist I/II to oversee translational assays and data analysis in support of ongoing clinical trials. You will identify pharmacodynamic and predictive biomarkers linked to NK cell–mediated responses, collaborating with Translational leadership to guide biomarker strategy and reporting.

This role requires hands-on flow cytometry, immunophenotyping, cytotoxicity and serum cytokine analysis, with strong immunology background and prior translational trial

Qualifications

• PhD in immunology or life sciences with translational/clinical trial experience.
• Experience in flow cytometry and biomarker development for autoimmunity preferred.
• Strong communication and collaboration skills for cross-functional teams.

Responsibilities

• Perform translational research related to autoimmune diseases.
• Develop and conduct cell-based assays (immunophenotyping, cytotoxicity, proliferation, cytokine analysis).
• QC flow cytometry data and monitor assay performance metrics.
• Support clinical biospecimen characterization, data analysis and reporting.
• Present findings at conferences and contribute to publications.
• Collaborate with Clinical Operations/Development on biomarker strategies.

Skills

Flow cytometry

Immunophenotyping

Cytotoxicity assays

Biomarker discovery

Translational science

Clinical trials

Education

PhD in immunology

MS with 10+ years in biotech

Tools

FlowJo

OMIQ

GraphPad Prism

Microsoft Office

Job description

About Artiva:

We are a clinical-stage biotechnology company focused on developing natural killer (NK) cell-based therapies. Our mission is to develop effective, safe, and accessible cell therapies for patients with devastating autoimmune diseases. We aim to develop therapies that patients and physicians can utilize in a community setting. Our lead product candidate, AlloNK®, is a non-genetically modified, cryopreserved NK cell therapy being evaluated in combination with B-cell targeted monoclonal antibodies (mAbs). We believe the compelling cell killing properties of NK cells, when combined with mAbs for targeting, creates an opportunity to generate potentially transformative therapies.

For more information, visit www.artivabio.com.

Job Summary:

Artiva Biotherapeutics is seeking a skilled and highly motivated Senior Scientist I/II who will be responsible for translational assay oversight and data analysis in support of ongoing clinical trials. This position will work with senior translational leadership to identify pharmacodynamic and predictive biomarkers associated with NK cell-mediated clinical response. The ideal candidate brings prior translational science experience supporting clinical trials, a strong background in immunology (B-cell immunology preferred), and hands-on expertise in flow cytometry analysis. The successful candidate will contribute to biomarker development and analysis to support ongoing clinical trials in autoimmunity.

Key Responsibilities:

• Perform cutting-edge translational research related to autoimmune diseases.
• Develop and conduct cell-based assays such as immunophenotyping, cytotoxicity, immune cell proliferation, serum cytokine/chemokine analysis.
• Perform quality control (QC) of flow cytometry data, including panel QC checks, staining and compensation controls, and ongoing monitoring of assay performance metrics.
• Work within Translational team to support clinical biospecimen characterization, data analysis, and reporting of results in the form of presentation or written reports for ongoing clinical trials.
• Present findings at scientific conferences and contribute to manuscript preparation for peer-reviewed publications.
• Leverage prior translational science experience to support clinical trial activities end-to-end, partnering with Clinical Operations and Clinical Development on biomarker strategy, sample logistics, and interpretation of clinical trial data.
• Process human clinical samples for biomarker analysis.
• Ensure compliance with protocols, SOPs and work practices.
• Comply with standard laboratory procedures and company policies, including notebook documentation and safety protocols.

Requirements

• PhD in immunology, life sciences or related discipline, with at least 5+ years of experience (6-7 years for Level II) or MS degree with 10+ years of experience within the biotechnology or pharmaceutical industry. Prior experience in translational science supporting clinical trials is preferred.
• Expertise in multi-parameter flow cytometry, including panel design, sample acquisition, data processing/analysis and QC; and immune cell functional assays (e.g. proliferation, cytokine production, cytotoxicity).
• A strong background in human immunology required, with an emphasis in B-cell immunology/biology desirable. Direct experience working in autoimmunity preferred.
• Prior experience in translational science with direct involvement in clinical trials (e.g., biomarker sample analysis, clinical data reporting, cross-functional collaboration with Clinical Development/Operations, and Data Management) strongly preferred.
• Strong understanding of drug development.
• Ability to work both independently and as part of a team, attention to detail and data quality, and excellent communication and interpersonal skills are required.
• Excellent computer skills with experience using flow cytometry analysis software, including FlowJo, OMIQ, GraphPad PRISM and Microsoft Office.

Competencies:

• Decision Making
• Attention to Detail
• Time Management
• Strategic Thinking
• Analysis & Reporting
• Written & Verbal Communication
• Cross-Functional Leadership & Mentoring

In addition to a great culture, we offer:

• A beautiful facility
• An entrepreneurial, highly collaborative, and innovative environment
• Comprehensive benefits, including:

• Medical, Dental, and Vision
• Group Life Insurance
• Long Term Disability (LTD)
• 401(k) Retirement Plan
• Employee Assistance Program (EAP)
• Flexible Spending Account (FSA)
• Paid Time Off (PTO)
• Company paid holidays, including the year-end holiday week
• Our recognition program, Bonus.ly, is where you can trade in points earned for things you want.

If all this speaks to you, come join us on our journey!

Base Salary: $149,000 - 183,000 annually. Exact compensation may vary based on level, skills and experience.