Senior Scientist I, Early Target Generation

ABBVIE; Cambridge (MA); On-site; USD 97,000 - 184,000; Full time

Job summary

AbbVie in Cambridge, MA is seeking a Senior Scientist I in the Exploratory Target Generation group to shape early program design and strategy for Immunology and Neuroscience targets.

The role focuses on expressing complex protein antigens, maintaining high-quality data, and partnering with Protein Sciences and CROs to advance candidates through discovery. Strong biochemistry expertise and collaboration across teams are essential for success.

Qualifications

• Ph.D., M.S. or B.S. in Biochemistry, Molecular and Cell Biology or related disciplines with typically 0-4 (Ph.D), 8-10 (M.S.), or 10-12+ (B.S.) years of experience
• Hands-on experience with mammalian suspension cell culture (HEK293 and CHO preferred) transient transfection, harvest and expression profiling is required
• Strong molecular biology skills and experience with sequencing tools and construct design is required (Geneious, Genedata)
• Experience using and interpreting standard protein analytical techniques (SDS-PAGE, Western blotting, BCA assays, endotoxin readings, size exclusion chromatography) is required
• Experience with a broad spectrum of protein purification techniques (affinity, ion exchange, size exclusion chromatography, etc), preferably using AKTA instrumentation is a plus
• Experience applying AI/ML workflows to improve laboratory workflows is desired
• Expertise in navigating and managing relationships with different protein vendors and CROs, ensuring alignment with project goals and timelines, is a plus
• Experience using GeneDataBiologics is a plus
• Strong Immunology and/or Neuroscience background is a plus
• Experience in protein expression from E. coli is a plus
• Proven research excellence demonstrated through a strong track record of publications, presentations and scientific achievements
• Demonstrated ability to actively participate and collaborate across cross-functional teams

Responsibilities

• Strategically engaged at the early exploratory stages of target selection within the Immunology and Neuroscience therapeutic areas
• Recombinant protein expression of antigens and cytokines supporting exploratory Immunology and Neuroscience therapeutic areas
• Innovatively design and produce soluble and membrane protein targets with enhanced stability for functional studies and antibody discovery
• Collaboration with Immunology and Neuroscience colleagues as representative of Protein Sciences, fostering the generation of innovative ideas and solutions
• Contribute to scientific excellence through dedication to multiple projects simultaneously, in a fast-paced, multi-disciplinary environment
• Demonstration of strong organizational and record keeping skills, ensuring timely delivery of requested material
• Clearly and effectively explain research findings and strategies, prioritizing transparency
• Collaborate with protein vendors and Contract Research Organizations (CROs) to secure, produce, and evaluate high-quality antigens
• Cultivate innovative problem-solving by generating original technical ideas and responding to scientific, regulatory, and competitive developments
• Maintain a strong knowledge of relevant publications pertaining to technological advancements, with an eye towards improving our workflows

Skills

Mammalian cell culture

HEK293

CHO cells

Transient transfection

Expression profiling

Molecular biology

Genedata

SDS-PAGE

Western blotting

Size exclusion chromatography

Education

Biochemistry, Molecular and Cell Biology

Tools

AKTA

Geneious

Job description

Senior Scientist I, Early Target Generation

• Full-time
• Salary Min: 96500
• Salary Max: 183500
• Workday Global Grade: 17
• Compensation: USD 96500 - USD 183500 - yearly

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com . Follow @abbvie onLinkedIn, Facebook ,Instagram ,X andYouTube.

Are you passionate about making a difference in patients’ lives?Are you interestedinbeing part of a team that helpscraft innovative solutionstocomplex problems? AbbVie's Discovery Biotherapeutics and Genetic Medicine (BGM)invitesyou to join us as aSeniorScientist Iin theExploratory Target Generation group ofProtein Sciencesteamat the Cambridge Research Center (CRC) site based in Cambridge, MA.This position offers the unique opportunity to participate in early program design and strategy, with a strong impact on our future pipeline.As a Senior Scientist you willberesponsible forexpressionof complexproteinantigens(cytokines, extracellular domains, membrane proteins, etc.)supportingexploratory programs in ourImmunology andNeuroscience therapeutic areas.The ideal candidate will have a strong protein biochemistry background,particularly inmammalian protein expression systems, and demonstrate a proven track record ofinnovative problem solvingas acontributor incross-functional collaborations.Strong verbal and written communication skills are required for effectively presenting scientific concepts and results to both scientific and non-scientific leaders. A significant research background, evidenced by a track record of publications, presentations, and scientific accomplishments, is highly desirable.

KeyResponsibilities:

Strategically engaged at the early exploratory stages of target selection within theImmunology andNeuroscience therapeutic areas

Recombinantprotein expressionofantigensand cytokinessupporting exploratory Immunology and Neuroscience therapeutic areas

Innovatively design and produce soluble and membrane protein targets with enhanced stability for functional studies and antibody discovery

Collaborationwith Immunology and Neuroscience colleagues asrepresentativeof Protein Sciences,fosteringthe generation of innovative ideas and solutions

Contribute to scientific excellence throughdedication to multiple projectssimultaneously,in a fast-paced, multi-disciplinary environment

Demonstration of strongorganizational and record keepingskills,ensuringtimely delivery of requested material

Clearly and effectively explain research findings and strategies,prioritizing transparency

Collaborate with protein vendors and Contract Research Organizations (CROs) to secure,produce, and evaluatehigh-quality antigens

Cultivate innovative problem-solving by generating original technical ideas and responding to scientific, regulatory, and competitive developments

Maintain a strong knowledge of relevant publications pertaining totechnologicaladvancements, with an eye towards improvingour workflows

Ph.D., M.S. or B.S.in Biochemistry, Molecular and Cell Biology or relateddisciplines with typically 0-4 (Ph.D), 8-10 (M.S.), or 10-12+ (B.S.) years of experience

Hands-on experience withmammalian suspension cell culture(HEK293 and CHO preferred)transient transfection, harvest and expression profiling is required

Strongmolecular biology skillsand experience with sequencing toolsand construct designisrequired(Geneious,Genedata)

Experienceusingand interpretingstandard protein analytical techniques (SDS-PAGE, Western blotting,BCA assays, endotoxin readings, size exclusion chromatography) is required

Experience with a broad spectrum of protein purification techniques (affinity, ion exchange, size exclusion chromatography,etc), preferably using AKTA instrumentation is a plus

Experience applying AI/ML workflows toimprove laboratory workflows is desired

Expertise in navigating and managing relationships with different protein vendors and CROs, ensuring alignment with project goals and timelines, is a plus

Experience usingGeneDataBiologics is a plus

Strong Immunology and/or Neuroscience background is a plus

Experience inprotein expression from e. coli is a plus

Proven research excellence demonstrated through a strong track record of publications, presentations and scientific achievements

Demonstrated ability toactively participate and collaborate across cross-functional teams

Buildsstrong relationships with peers and cross-functionally with partners outside the team to deliver high performance

Learnsfast,graspsthe "essence" and can change course quicklywhereindicated

Raises the bar and is never satisfied with the status quo

Creates a learning environment, open to suggestions and experimentation for improvement

Embraces the ideas of others, nurtures innovation and manages innovation to reality

AbbVie is committed to fostering an inclusive and diverse work environment. Be part of our team that is curious, open-minded, and ready to tackle the biotherapeutic challenges of tomorrow!

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or anyother form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

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