Senior Scientist I, Early Target Generation

Allergan; Cambridge (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

AbbVie in Cambridge, MA is seeking a Senior Scientist I in Exploratory Target Generation within Protein Sciences at the CRC site. You will help shape early program design for Immunology/Neuroscience, expressing complex proteins and antigens to support exploratory studies.

Collaboration across teams and with CROs will be essential to drive innovative solutions. The ideal candidate has a strong protein biochemistry background, expertise in mammalian systems, and a proven track record of

Qualifications

• Ph.D./M.S./B.S. with extensive experience in protein biochemistry and mammalian expression.
• Hands-on mammalian culture, transfection, expression profiling and data interpretation.
• Strong molecular biology skills and experience with sequencing and construct design.
• Proven publication record and ability to work across teams.

Responsibilities

• Engage early in exploratory target generation for Immunology/Neuroscience.
• Express recombinant antigens and cytokines for studies.
• Design and produce soluble/membrane protein targets with stability.
• Collaborate with Immunology/Neuroscience teams and vendors.
• Deliver multiple projects in a fast-paced, multidisciplinary setting.
• Maintain organized records and timely material delivery.
• Communicate findings clearly to scientific and non-scientific leaders.
• Coordinate with CROs to produce high-quality antigens.

Skills

Mammalian cell culture

Transfection

Molecular biology

Protein expression

Cross-functional collaboration

Scientific communication

Education

Ph.D. in Biochemistry/Molecular & Cell Biology

M.S. in relevant field

B.S. in relevant field

Tools

Geneious

Genedata

AKTA

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, Xand YouTube.

Job Description

Are you passionate about making a difference in patients’ lives?Are you interestedinbeing part of a team that helpscraft innovative solutionstocomplex problems? AbbVie's Discovery Biotherapeutics and Genetic Medicine (BGM)invitesyou to join us as aSeniorScientist Iin theExploratory Target Generation group ofProtein Sciencesteamat the Cambridge Research Center (CRC) site based in Cambridge, MA.This position offers the unique opportunity to participate in early program design and strategy, with a strong impact on our future pipeline.As a Senior Scientist you willberesponsible forexpressionof complexproteinantigens(cytokines, extracellular domains, membrane proteins, etc.)supportingexploratory programs in ourImmunology andNeuroscience therapeutic areas.The ideal candidate will have a strong protein biochemistry background,particularly inmammalian protein expression systems, and demonstrate a proven track record ofinnovative problem solvingas acontributor incross-functional collaborations.Strong verbal and written communication skills are required for effectively presenting scientific concepts and results to both scientific and non-scientific leaders. A significant research background, evidenced by a track record of publications, presentations, and scientific accomplishments, is highly desirable.

KeyResponsibilities:

• Strategically engaged at the early exploratory stages of target selection within theImmunology andNeuroscience therapeutic areas
• Recombinantprotein expressionofantigensand cytokinessupporting exploratory Immunology and Neuroscience therapeutic areas
• Innovatively design and produce soluble and membrane protein targets with enhanced stability for functional studies and antibody discovery
• Collaborationwith Immunology and Neuroscience colleagues asrepresentativeof Protein Sciences,fosteringthe generation of innovative ideas and solutions
• Contribute to scientific excellence throughdedication to multiple projectssimultaneously, in a fast-paced, multi-disciplinary environment
• Demonstration of strongorganizational and record keepingskills,ensuringtimely delivery of requested material
• Clearly and effectively explain research findings and strategies,prioritizing transparency
• Collaborate with protein vendors and Contract Research Organizations (CROs) to secure,produce, and evaluatehigh-quality antigens
• Cultivate innovative problem-solving by generating original technical ideas and responding to scientific, regulatory, and competitive developments
• Maintain a strong knowledge of relevant publications pertaining totechnologicaladvancements, with an eye towards improvingour workflows

Qualifications

• Ph.D., M.S. or B.S.in Biochemistry, Molecular and Cell Biology or relateddisciplines with typically 0-4 (Ph.D), 8-10 (M.S.), or 10-12+ (B.S.) years of experience
• Hands-on experience withmammalian suspension cell culture(HEK293 and CHO preferred)transient transfection, harvest and expression profiling is required
• Strongmolecular biology skillsand experience with sequencing toolsand construct designisrequired(Geneious,Genedata)
• Experienceusingand interpretingstandard protein analytical techniques (SDS-PAGE, Western blotting,BCA assays, endotoxin readings, size exclusion chromatography) is required
• Experience with a broad spectrum of protein purification techniques (affinity, ion exchange, size exclusion chromatography,etc), preferably using AKTA instrumentation is a plus
• Experience applying AI/ML workflows to improve laboratory workflows is desired
• Expertise in navigating and managing relationships with different protein vendors and CROs, ensuring alignment with project goals and timelines, is a plus
• Experience usingGeneDataBiologics is a plus
• Strong Immunology and/or Neuroscience background is a plus
• Experience inprotein expression from e. coli is a plus
• Proven research excellence demonstrated through a strong track record of publications, presentations and scientific achievements
• Demonstrated ability toactively participate and collaborate across cross-functional teams

Key Competencies:

• Buildsstrong relationships with peers and cross-functionally with partners outside the team to deliver high performance
• Learnsfast,graspsthe "essence" and can change course quicklywhereindicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others, nurtures innovation and manages innovation to reality

AbbVie is committed to fostering an inclusive and diverse work environment. Be part of our team that is curious, open-minded, and ready to tackle the biotherapeutic challenges of tomorrow!

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Nota amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto R...ciation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html