Senior Scientist, Conjugation Process Development

Pfizer; Bothell (WA); On-site; USD 94,000 - 156,000; Full time

Job summary

Pfizer is seeking a Senior Scientist to lead antibody-drug conjugate (ADC) process development projects from early-phase to late-stage or commercial products. You will mentor team members and forecast resources while applying cutting-edge design and process development capabilities to accelerate breakthrough therapies.

The role emphasizes Quality and cross-functional collaboration. The position is on premise with a base salary range and bonus eligibility, reflecting location-based compensation.

Qualifications

• Must Have Bachelor's Degree with 9 to11 years of experience, Master's Degree with 7 to 8 years of experience, or PhD and 0-3 years of experience
• Direct experience with antibodies, proteins, and/or bioconjugation
• Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS)
• Willingness to work with highly potent cytotoxic molecules
• Ability to perform complex data analysis
• Excellent oral and written communication skills
• Foundational understanding of organic chemistry, reaction mechanisms, and process development

Responsibilities

• Independently design, execute, and interpret studies intended to answer a defined question within the defined timeframe.
• Design subsequent experiments upon interpretation of data.
• Monitor results, identify problems, and develop solutions.
• Facilitate technology/assay transfers internally/externally.
• Regularly contribute at department and project team level and represent the group on multidisciplinary teams.
• May present at national/international forums.
• Author and review technical reports, manufacturing documents, regulatory submissions and publications.
• Identify areas for process improvement and technology development and propose solutions.

Skills

Antibody conjugation

Protein analytics

Data analysis

Oral and written communication

Education

Bachelor's degree in chemistry/biochemistry/chemical engineering

Master's degree

PhD (optional)

Tools

JMP

GMP manufacturing

Tangential flow filtration

Job description

Job Description Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be a member of our growing Conjugation Process Development team and will lead antibody-drug conjugate (ADC) process development projects ranging from early-phase clinical molecules through late-stage or commercial products. You will contribute to the development of ADC products targeting cancer to make a meaningful difference in people’s lives. You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members. It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

Role responsibilities

• Independently design, execute, and interpret studies intended to answer a defined question within the defined timeframe.
• Design subsequent experiments upon interpretation of data.
• Monitor results, identify problems, and develop solutions.
• Facilitate technology/assay transfers internally/externally.
• Regularly contribute at department and project team level and represent the group on multidisciplinary teams.
• May present at national/international forums.
• Author and review technical reports, manufacturing documents, regulatory submissions and publications.
• Identify areas for process improvement and technology development and propose solutions.

Qualifications

• Must Have Bachelor's Degree with 9 to11 years of experience, Master's Degree with 7 to 8 years of experience, or PhD and 0-3 years of experience Degree in chemistry, biochemistry, chemical engineering, or related field Direct experience with antibodies, proteins, and/or bioconjugation Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS) Willingness to work with highly potent cytotoxic molecules Ability to perform complex data analysis Excellent oral and written communication skills Foundational understanding of organic chemistry, reaction mechanisms, and process development

Nice to Have

• Experience with tangential flow filtration
• Experience using statistical and data analysis software, such as JMP, for experimental design, data visualization, and interpretation.
• Experience with GMP manufacturing
• Familiarity with CMC team function
• Experience with technology transfer to manufacturing
• Familiarity with chemical synthesis, protein modification, bioconjugation chemistry, and the application of analytical technologies to process development

Other Job Details

Work Location Assignment: On Premise

The annual base salary for this position ranges from $93,600.00 to $156,000.00.

In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program.

We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.

Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com).

Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.

Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.

If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [e-mail]. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

Research and Development

Pfizer careers are like no other. In our culture of individual ownership, we believe in our ability to improve future healthcare, and potential to transform millions of lives. We’re looking for new talent to join our global community, to unearth new innovative therapies that make the world a healthier place.