Senior Scientist, Computational Biology- Oncology Translational Research

Johnson & Johnson Innovative Medicine; Spring House (PA); On-site; USD 105,000 - 175,000; Full time

Benefits offered by this job

Vacation – 120 hours/year

Sick time – 40 hours/year

Floating holidays

401(k) retirement plan

Comprehensive health benefits

Job summary

Johnson & Johnson Innovative Medicine is seeking a Senior Scientist in Translational Oncology Computational Biology to lead analysis of complex biomarker and clinical data, driving insights for oncology development. The role spans Spring House, PA, and other sites, with collaboration across Translational Research and Data Science.

The candidate will apply advanced bioinformatics, statistics, and machine-learning methods to inform decision-making and publish results, while partnering with

Qualifications

• PhD in Bioinformatics, Computational Biology, Biostatistics, Genomics, Data Science, or related field with 1–3 years in industry.
• Advanced proficiency in R, and experience in Python, Linux/Unix, shell scripting, version control, and reproducible analyses of high-throughput data.
• Strong oncology translational or clinical-development experience and cancer-biology knowledge.
• Strong statistical and machine-learning experience (regression, survival, supervised/unsupervised learning, reinforcement learning).
• Ability to communicate complex analyses clearly and work across functions with peer-reviewed outputs.

Responsibilities

• Analyze multimodal oncology biomarker data and associated clinical outcomes (DNA/RNA sequencing, proteomics, single-cell, spatial transcriptomics).
• Integrate molecular, pathological, and clinical data to identify and evaluate biomarkers.
• Support translational strategies through trial-design knowledge and endpoints.
• Use AI-enabled tools responsibly with validated, traceable outputs.
• Collaborate with cross-functional teams and contribute to publications and presentations.

Skills

PhD in bioinformatics / computational/

R proficiency

Python

Linux/Unix

Shell scripting

Version control

Multimodal omics data analysis

Education

PhD in a quantitative field

Tools

R

Python

Linux/Unix

Shell scripting

Version control

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Translational Discovery & Development Biomarkers

Job Category

Scientific/Technology

All Job Posting Locations

Cambridge, Massachusetts, United States of America, La Jolla, California, United States of America, Spring House, Pennsylvania, United States of America

Job Description

Senior Scientist, Computational Biology- Oncology Translational Research

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

About Oncology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are seeking a highly motivated senior scientist to join our translational research team based in Spring House, PA, Cambridge, MA, La Jolla, CA.

Position Summary

The Senior Scientist, Computational Biology- Oncology Translational Research, will be responsible for analysis, interpretation and integration of complex, multimodal omics, biomarker, and clinical data. The individual will apply rigorous AI-enabled bioinformatics, statistical, and machine-learning approaches to generate insights that meaningfully inform oncology clinical development, while partnering closely with Translational Research Leaders, Clinical Development, Statistics, Programming, Pathology, Diagnostics, Data Science, Regulatory, and Biomarker Operations.

Essential Job Duties And Responsibilities

• Independently analyze multimodal oncology biomarker data and associated clinical outcomes, including DNA/RNA sequencing, flow cytometry, proteomics, single-cell and spatial transcriptomics data, applying cancer biology expertise, rigorous statistical and machine-learning methods to generate biologically and clinically relevant insight.
• Integrate molecular, pathological, and clinical data to identify, validate and evaluate pharmacodynamic, prognostic, predictive, and resistance biomarkers.
• Leverage computational evidence to support the development of translational strategies, using working knowledge of trial design, endpoints, and treatment response.
• Use approved AI-enabled tools responsibly to accelerate analysis, coding, testing, and documentation while ensuring that all outputs are reviewed, validated, traceable, and reproducible.
• Collaborate with cross-functional study and program teams; clearly communicate findings, uncertainty, and limitations; and contribute to publications, presentations, and evaluation of emerging computational and biomarker technologies.

Required Qualifications

• PhD in Bioinformatics, Computational Biology, Biostatistics, Genomics, Data Science, or a related quantitative field, with 1-3 years of relevant pharmaceutical or biotechnology industry experience.
• Advanced proficiency in R, with experience in Python, wLinux/Unix, shell scripting, version control, and reproducible analysis of high-throughput sequencing and multimodal omics data.
• Demonstrated oncology translational or clinical-development experience, with strong knowledge of cancer biology, biomarker applications, and clinical-trial concepts.
• Strong statistical and machine-learning experience, including regression, multivariate data analysis, survival analysis, supervised learning, semi-supervised learning, unsupervised learning, reinforcement learning for the analysis of biomarker, assay, and clinical data.
• Ability to communicate complex analyses and their limitations clearly, collaborate across functions, and independently own defined study or biomarker-analysis workstreams.
• Demonstrated scientific accomplishments through peer-reviewed publications and scientific presentations.

Preferred Qualifications

• Familiarity with CDISC SDTM and ADaM data models, regulatory clinical data management practices, and biomarker-data traceability.
• Experience with deep learning, multimodal modeling, or responsible application of foundation models or agentic AI to biomedical research.
• Working knowledge of IND and NME development and Phase 1–3 clinical trials, including study design, dose escalation and expansion, analysis populations, clinical endpoints, longitudinal and time-to-event analyses, and interpretation of biomarker data as decision-informing evidence.
• Experience supporting patient-selection, companion or complementary diagnostic, regulatory, or submission-related biomarker activities.

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Company’s long-term incentive program.

Benefits

• Vacation –120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
• Holiday pay, including Floating Holidays –13 days per calendar year
• Work, Personal and Family Time - up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave – 80 hours in a 52-week rolling period10 days
• Volunteer Leave – 32 hours per calendar year
• Military Spouse Time-Off – 80 hours per calendar year

For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

The anticipated base pay range for this position is:$105,000 - $169,050

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

Required Skills

Preferred Skills:

Biomarkers, Clinical Trial Designs, Coaching, Communication, Critical Thinking, Drug Discovery Development, Human-Centered Design, Interdisciplinary Work, Medical Compliance, Medical Technology, Quality Standards, Research Documents, Safety-Oriented, Scientific Research, Technologically Savvy, Translational Medicine

The anticipated base pay range for this position is :

$109,000.00 - $174,800.00