Senior Scientist, Data (AI) Scientist, Translational Safety

6084-Janssen Research & Development, LLC Legal Entity; Spring House (PA); On-site; USD 109,000 - 175,000; Full time

Job summary

Johnson & Johnson is seeking a Senior Translational AI Scientist to join the Data, Data Science & Artificial Intelligence (DDSAI) – OCMO organization, accelerating safety prediction across drug discovery and development with advanced AI/ML analytics and multimodal data.

The role develops predictive models identifying translational biomarkers and high translational-risk compounds, enabling optimal risk minimization while collaborating with scientists from preclinical to real-world evidence

Qualifications

• Ph.D. or equivalent experience; preferred in quantitative life sciences or CS.
• AI/ML experience in life-sciences settings (industry or post-doc). 2+ years post-PhD or 3–5 years industry.
• Domain expertise in translational science, biomarker discovery, safety assessment or related drug-discovery applications.
• Publications in top-tier venues preferred.
• Strong programming in Python with ML frameworks; deep knowledge of transformers, CNNs, graph networks, and causal inference.

Responsibilities

• Design, build, validate and deploy AI/ML solutions for translational safety across discovery, preclinical, clinical and RWE domains.
• Develop predictive models and AI‑reasoning frameworks for translational safety and biomarker identification.
• Integrate high‑dimensional datasets (imaging, omics, EHR, claims) to derive insights and inform portfolio decisions.
• Establish scientific validation with explainability and regulatory-friendly evidence packages.
• Prototype foundation-model connectors to link discovery to RWD and support closed-loop learning.
• Collaborate with translational scientists and data teams to operationalize models.
• Communicate complex methods clearly and maintain reproducible code and docs.

Skills

Advanced Analytics

Business Intelligence

Coaching

Collaboration

Critical Thinking

Data Analysis

Database Management

Data Privacy Standards

Data Reporting

Data Savvy

Data Science

Data Visualization

Econometric Models

Process Improvements

Technical Credibility

Technologically Savvy

Workflow Analysis

Education

Ph.D. preferred in Computational Biology, Bioinformatics, Biomedical Informatics, Computer Science, Statistics, Applied Mathematics or related quantitative discipline; or equivalent experience

Tools

Python

PyTorch

TensorFlow

Multimodal Data Fusion

Foundation Models

Job description

Job Function

Data Analytics & Computational Sciences

Job Sub Function

Data Science

Job Category

Scientific/Technology

All Job Posting Locations

• Cambridge, Massachusetts, United States of America
• Horsham, Pennsylvania, United States of America
• New Brunswick, New Jersey, United States of America
• Raritan, New Jersey, United States of America
• Spring House, Pennsylvania, United States of America
• Titusville, New Jersey, United States of America

Job Description

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

Position Summary Senior Scientist – Data (AI) Scientist, Translational Safety

to join the Data, Data Science & Artificial Intelligence (DDSAI) – OCMO (Office of Chief Medical Officer) organization helping accelerate drug safety prediction across all stages of drug discovery and development, using advanced AI/ML analytics and multimodal modeling of biological (preclinical and clinical) and RWE data. The Senior Translational AI Scientist will develop predictive models that identify translational-biomarkers and flag compounds with high translational-safety risk, enabling optimal risk minimization supporting patient benefit/risk decisions. One exciting opportunity will be to support the development of AI-enabled reasoning capabilities and Foundation models that connect discovery, preclinical, clinical, and real-world evidence domains to accelerate translational safety predictions. This role will partner closely with pharmaceutical scientists across all phases as well as other Data Scientists from Knowledge Engineering and Data Products to transform harmonized, AI-ready data assets into actionable scientific insights that improve decision-making across the R & D lifecycle.

Mission

Develop scientifically credible AI and machine learning capabilities and models that enable earlier prediction of safety and efficacy outcomes and support closed-loop learning across drug discovery and development.

Strategic rationale (why this role matters) Builds the capability for AI-driven, translationally-focused predictive models that identify safety biomarkers and flag high translational-risk compounds earlier in the R & D lifecycle in the forward direction, and also support reverse-translation of AE (Adverse event) Signals from RWE by feeding back causal inference insights to preclinical and clinical. Directly supports faster, evidence-based go/no‑go and risk‑minimization decisions, increasing program productivity and protecting patient safety. Enables development of cross-domain Foundation models and AI reasoning that connect discovery to preclinical to clinical to RWE, creating reusable IP and accelerating future projects.

Key responsibilities

• Design, build, validate and deploy AI/ML solutions for translational safety prediction using multimodal data across discovery, preclinical, clinical and real‑world evidence (RWE) domains.
• Develop predictive models and AI‑reasoning frameworks for translational safety, biomarker identification, mechanistic inference and clinical outcome prediction; evaluate traditional ML, deep learning, causal inference and foundation‑model approaches.
• Integrate heterogeneous, high‑dimensional datasets (e.g., high‑content imaging, phenomics, transcriptomics, proteomics, EHR, claims) to derive novel biological insights that de‑risk safety signals and inform portfolio decisions.
• Establish scientific validation: assess biological plausibility, benchmark model performance, produce explainability and validation packages suitable for regulatory and cross‑functional review.
• Prototype and advance Foundation‑model connectors and AI‑enabled reasoning to link discovery to preclinical to clinical to RWE and support closed‑loop learning across R&D.
• Collaborate closely with translational scientists, toxicology, clinical safety, PV, Knowledge Engineering, Data Products and external partners to prioritize use cases, operationalize models and drive productization.
• Communicate complex technical methods and results clearly to diverse audiences and stakeholders; maintain reproducible code, documentation and up‑to‑date versioned repositories.

Qualifications

• Education: Ph.D. preferred in Computational Biology, Bioinformatics, Biomedical Informatics, Computer Science, Statistics, Applied Mathematics or a related quantitative discipline; or equivalent experience.
• Experience: demonstrated experience applying AI/ML in life‑sciences settings (industry or post‑doc); typically 2+ years post‑PhD or ~3–5 years relevant industry experience.
• Domain expertise: track record in translational science, biomarker discovery, safety assessment or related drug‑discovery applications.
• Publication history or demonstrated contributions to top‑tier conferences/journals preferred.
• Technical skills: Strong programming proficiency, preferably Python, and experience with AI frameworks (PyTorch or TensorFlow). Deep knowledge of ML/DL methods (Transformers, CNNs, graph networks, self‑supervised and multi‑instance learning), causal inference and graph analytics. Experience with multimodal representation learning, foundation models, LLMs/GraphRAG and multimodal data fusion. Practical experience analyzing imaging/microscopy, multi‑omics and real‑world clinical data at scale.
• Capabilities & behaviors: excellent analytical thinking, scientific rigor, strong written and oral communication, collaborative cross‑functional influence, and the ability to translate domain questions into robust AI solutions.
• Nice‑to‑have: prior experience producing regulatory‑acceptable model evidence, operationalizing models into decision workflows, or building reusable model assets for R&D programs.

Johnson & Johnson is an Equal Opportunity Employer.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

Required Skills: Preferred Skills

• Advanced Analytics
• Business Intelligence (BI)
• Coaching
• Collaboration
• Critical Thinking
• Data Analysis
• Database Management
• Data Privacy Standards
• Data Reporting
• Data Savvy
• Data Science
• Data Visualization
• Econometric Models
• Process Improvements
• Technical Credibility
• Technologically Savvy
• Workflow Analysis

The anticipated base pay range for this position is : $109,000.00 - $174,800.00

Additional Description for Pay Transparency

• Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
• Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation –120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
• Holiday pay, including Floating Holidays –13 days per calendar year
• Work, Personal and Family Time - up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave – 80 hours in a 52-week rolling period10 days Volunteer Leave – 32 hours per calendar year Military Spouse Time-Off – 80 hours per calendar year
• For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at https://www.jnj.com/.

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