Senior Scientist, Cardiovascular NAMs & CIVMs

BioSpace; Indianapolis (IN); On-site; USD 129,000 - 211,000; Full time

Benefits offered by this job

Company bonus

Comprehensive benefits

Job summary

Lilly is seeking a scientist to anchor cardiovascular NAMs within the Investigative Toxicology group. The role emphasizes hiPSC models, 3D cardiovascular platforms, and translatable readouts to assess drug-induced liabilities across the cardiovascular system.

Ideal candidates hold a PhD with 2+ years postdoc/industry experience in advanced cardiovascular in vitro models, and will collaborate across internal and external partners to advance safety pharmacology and translational science.

Qualifications

• PhD with training in cardiac biology or cardiovascular electrophysiology.

Responsibilities

• Develop human-relevant in vitro cardiovascular models.
• Design mechanistic studies on proarrhythmia and cardiomyopathy.
• Implement electrophysiological and contractile readouts (MEA, calcium, sarcomere assays).
• Utilize 3D platforms (EHTs/COs) for chronic dosing studies.
• Collaborate with CROs and internal teams on study design and data quality.
• Engage in pre-competitive consortia and publish externally.

Skills

hiPSC-CM differentiation

MEA-based proarrhythmia

3D EHT functional assessment

Endothelial cell/vessel-on-a-chip

collaborative teamwork

Education

PhD in Pharmacology/Physiology/Toxicology

2+ years postdoc/industry experience

leadership experience

Tools

MEA systems

3D CIVM platforms

Ca2+ imaging

Job description

Lilly is seeking a scientist to anchor cardiovascular NAMs within the Investigative Toxicology group. The role emphasizes hiPSC models, 3D cardiovascular platforms, and translatable readouts to assess drug-induced liabilities across the cardiovascular system.

Ideal candidates hold a PhD with 2+ years postdoc/industry experience in advanced cardiovascular in vitro models, and will collaborate across internal and external partners to advance safety pharmacology and translational science.