Senior Scientist, Cardiovascular & Metabolic Disease

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 100,000 - 182,000; Full time

Job summary

Flagship Pioneering, Inc. is seeking an exceptional Scientist or Senior Scientist to lead discovery efforts in cardiovascular and metabolic disease. You will shape our pipeline, bringing scientific leadership to target validation and early drug discovery strategies.

This cross-functional role involves collaboration with platform scientists, computational biologists, and drug discovery teams to advance novel targets into development. A Ph.D.

Qualifications

• Ph.D. in physiology, pharmacology, cell biology, or a related field; postdoctoral training or industry experience strongly preferred.
• 2 years (Scientist) or 5 years (Senior Scientist) of relevant postdoctoral or industry experience.
• Experience with cellular assays and in vitro pharmacology assays; hands-on techniques in CRISPR, ELISA, qPCR, Western blotting, and RNAseq.
• Strong track record of scientific contributions (publications, patents, presentations).
• Excellent communication, collaboration, and organizational skills in a fast-paced environment.

Responsibilities

• Drive discovery research in cardiovascular and/or metabolic disease areas by designing, executing, and interpreting mechanistic studies using state-of-the-art models and technologies.
• Lead target validation efforts informed by proteomic and computational insights; develop hypotheses and prioritize targets with high translational potential.
• Collaborate with computational biology and proteomics teams to interpret large-scale datasets and generate novel biological insights.
• Design and oversee in vitro and in vivo models of disease to support target biology, candidate selection, biomarker development, and proof-of-concept studies.
• Contribute to building and refining the company’s therapeutic strategy in CVD/metabolic disease.
• Communicate findings clearly and effectively in cross-functional team meetings, external collaborations, and leadership presentations.
• Support or lead external academic and industry collaborations.

Skills

CRISPR

ELISA

qPCR

RNAseq

assay development

protein biology

Education

Ph.D. in physiology, pharmacology, cell biology, or related field

Job description

Flagship Pioneering, Inc. is seeking an exceptional Scientist or Senior Scientist to lead discovery efforts in cardiovascular and metabolic disease. You will shape our pipeline, bringing scientific leadership to target validation and early drug discovery strategies.

This cross-functional role involves collaboration with platform scientists, computational biologists, and drug discovery teams to advance novel targets into development. A Ph.D.