Research Associate II/Senior Research Associate

Systimmune; Bothell (WA); On-site; USD 70,000 - 90,000; Full time

Benefits offered by this job

Comprehensive benefits

401(k) plan with company match

Job summary

SystImmune in Bothell, WA is seeking a Research Associate II or Senior Research Associate to support downstream protein purification, characterization, and process development for preclinical and clinical candidates.

You will report to a Downstream lead, operate ÄKTA systems, perform purifications and analytical assays, and contribute to tech transfer to GMP manufacturing while occasionally working outside normal hours.

Qualifications

• MS or BS in Protein Science, Chemical Engineering, Biochemistry or related field.
• 2+ years industry experience for Research Associate II; BS with 5+ years or MS with 3+ years for Senior.
• Experience with protein chromatography and filtration methods.
• Ability to execute SOPs and biophysical assays for process development.

Responsibilities

• Assist in downstream process development of molecules in pre-clinical and clinical pipelines.
• Perform routine purifications and analytical assays to support cell-line development, upstream, analytical, and formulation groups.
• Execute development experiments to produce scalable and robust purification processes (affinity chromatography, IEX, HIC, CHT) and viral inactivation/filtration processes.
• Generate low endotoxin production runs for pre-clinical studies.
• Compile, analyze, and report data for process development and tech transfer documents.
• Author SOPs for biophysical assays and workflows.
• Participate in timeline planning.

Skills

Protein science background

Biopharmaceutical industry experience

Downstream process development

Education

MS or BS in Protein Science, Chemical Engineering, Biochemistry or related field

Tools

ÄKTA Protein Purification Systems

Unicorn software

SEC-HPLC/UPLC

Tangential Flow Filtration

Viral inactivation/filtration methods

Job description

SystImmuneis a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs).SystImmunehas multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials.SystImmunehas a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

The Research Associate II/Senior Research Associate will assist in downstream protein purification, protein characterization, and process development. The position will directly report to a Downstream lead and assist in downstream process development and tech transfer to a GMP manufacturing facility. In this role, the individual will assist and operate both routine and advanced analytical instruments as well as protein purification systems.

This position is full-time onsite at our new Bothell, WA location. This role may occasionally need to work outside normal work hours.

Key Responsibilities:

• Assist in downstream process development of molecules in pre-clinical and clinical pipelines. Process development activities include buffer preparation, chromatography method development and execution, TFF, and filtration operations and development
• Assist in performing routine purifications and analytical assays to support cell-line development, upstream, analytical, and formulation groups
• Execute development experiments to produce scalable and robust purification processes via affinity chromatography, IEX, HIC and CHT, etc, using the ÄKTA FPLC platform. Execute development experiments to produce scalable and robust viral inactivation, viral filtration and tangential flow filtration process
• Generate low endotoxin production runs for pre-clinical studies
• Perform routine HPLC/UPLC, CE, cIEF, octet, ELISA and other biophysical techniques to support upstream, downstream, and formulation process development
• Compile, analyze, and report data for process development, tech transfer documentation, and other internal partners
• Author standard operating procedures for biophysical assays and standard workflows
• Participate in timeline planning
• Other duties as assigned

Required Skills & Qualifications:

• MS or BS in Protein Science, Chemical Engineering, Biochemistry or a related field and relevant pharmaceutical or biotech experience
• Research Associate II - requires 2+ years of industry experience
• Senior Research Associate - requires BS with 5+ years of experience or MS degree with 3+ years of industry experience
• Experience with protein chromatography and filtration methods, and protein analysis techniques
• Ability to execute SOPs and biophysical assays, and experiments designed for process development of pipeline molecules independently
• Hands-on experience in:
  • ÄKTA Protein Purification Systems and Unicorn software
  • SEC-HPLC/UPLC
  • Purification Process Development
  • Crossflow and Tangential Flow Filtration techniques
  • Column packing / unpacking
  • Viral inactivation and viral filtration process development / Viral clearance study
  • Low endotoxin production run
  • Process scale-down/scale-up

Compensation and Benefits:

The expected base salary range for this position is $70,000 - $90,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.

While most offers typically fall within thelow to mid-pointof the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmuneis a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.SystImmuneoffers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmuneis an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.