Senior Scientist, AI‑Driven RNA Oligonucleotide Design

The RNA Society; Indiana (PA); On-site; USD 117,000 - 180,000; Full time

Job summary

NATi in Singapore is seeking a Computational Scientist to build pipelines and predictive models for ASOs, siRNAs, and mRNA across therapeutic applications. You will scale bioinformatics and AI/ML capabilities to accelerate design and optimization of oligonucleotide candidates with translational potential.

Collaborating with chemists, biologists, and pharmacologists, you will translate computational insights into experimentally validated candidates, contribute to IP, and stay current with new

Qualifications

• PhD in Computational Chemistry, Biophysics, Bioinformatics, Biomedical Engineering, or related field.
• 4+ years (Scientist) or 8+ years (Senior Scientist) hands-on industry experience in computational oligonucleotide design or RNA-targeting therapeutics.
• Strong scripting in Python/R and ML frameworks; experience with reproducible research practices.
• Proficiency in RNA structure prediction and interaction modelling tools.
• Experience with nucleotide modification strategies and integrating into design workflows.

Responsibilities

• Drive RNA therapeutic design and computational optimisation, integrating RNA biology and chemistry.
• Develop automated data processing and visualization pipelines for drug property analyses.
• Apply AI/ML to explore chemical space and predict oligonucleotide properties.
• Analyze large biological datasets to inform design and modification strategies.
• Create models combining sequence, structure, and chemistry to predict target engagement.

Skills

Python

R scripting

ML frameworks

data pipelines

git

reproducible research

Education

PhD in Computational Chemistry/Biophysics/Bioinformatics/Biomedical Engineering

Tools

RNAstructure

ViennaRNA

IntaRNA

RNAhybrid

RNA-Seq

Job description

NATi in Singapore is seeking a Computational Scientist to build pipelines and predictive models for ASOs, siRNAs, and mRNA across therapeutic applications. You will scale bioinformatics and AI/ML capabilities to accelerate design and optimization of oligonucleotide candidates with translational potential.

Collaborating with chemists, biologists, and pharmacologists, you will translate computational insights into experimentally validated candidates, contribute to IP, and stay current with new