Senior Scientist

Roche Holdings Inc.; Seattle (WA); On-site; USD 94,000 - 175,000; Full time

Job summary

Join a leading company in healthcare innovation as a Molecular Engineer in Seattle. You'll work on cutting-edge DNA sequencing technology, leading experiments and cross-functional teams. Your expertise in organic synthesis and chemistry will directly impact patient outcomes. With a collaborative culture, you will thrive while contributing to significant advancements in healthcare. Relocation benefits available, and competitive salary based on experience.

Benefits

Relocation Benefits

Discretionary Annual Bonus

Qualifications

• 6 years of laboratory experience in advanced nucleotide chemistry.
• Experience with complex organic synthesis.

Responsibilities

• Research, design, and execute innovative experiments.
• Lead and mentor cross-functional teams.
• Develop SOPs for reagent production.

Skills

Laboratory Experience

Problem Solving

Data Analysis

Education

Bachelor's degree in Organic Synthesis

Master's degree in Chemistry

PhD in Biochemistry

Tools

HPLC

MS

NMR

Automated DNA Synthesizers

Job description

At Roche, you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted, and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop, and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

We advance science so that we all have more time with the people we love.

Roche Diagnostics acquired Stratos Genomics in 2020 for its unique chemistry that advances DNA sequencing by nanopore, Sequencing by Expansion (SBX). You will engineer and synthesize the molecular building blocks for our novel technology. These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing.

The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes. We are looking for people who are excited about the significance of our technology and want to make SBX successful.

The Opportunity:

• Research, design, and execute innovative and well-controlled experiments, with high attention to detail.

• Lead, mentor, and drive cross-functional teams.

• Identify and troubleshoot problems in creative ways.

• Contribute to the definition and timely achievement of project goals.

• Develop SOPs to aid in the production of reagents and starting materials.

• Participate in the production of reagents and starting materials.

• Perform data analysis and protocol development.

• Maintain accurate, detailed, and reliable laboratory records.

• Present findings at group or departmental meetings.

• Maintain the lab's cleanliness and organization.

• Develop and propose improved processes to fulfill the above functions.

Who You Are:

• You have 6 years of laboratory experience in advanced nucleotide/heterocyclic chemistry, phosphorus chemistry, and/or complex/multi-step organic synthesis.

• You have a Bachelor's degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry, or a related field, and 8 years of experience, or a Master's degree in the same fields with 7 years of experience, or a PhD in the same fields with 4 years of experience.

• Ideally, you will have:

  • Demonstrated ability to understand and develop chemistry for:

    • Nucleotides

    • Phosphoramidites

    • Heterocycles

    • Amino Acids

    • Bio-conjugations

  • Mature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification, and storage.

  • Technical background in next-generation DNA sequencing.

  • Experience with HPLC, MS, NMR, automated DNA synthesizers, inert atmosphere chambers, and manual pipetting.

Application instructions:

• Include a cover letter addressing:

• Clearly state your motivation for wanting to work with us.

• Describe your specific technical interest in SBX technology and how you envision contributing.

• Outline potential challenges related to the molecular engineering of SBX technology and propose solutions.

Submitting a comprehensive cover letter that addresses these points is necessary.

Relocation benefits are available. The expected salary range for Seattle, WA is $94,200 - $175,000. Actual pay will be based on experience, qualifications, geographic location, and other factors. A discretionary annual bonus may also be available.

This position qualifies for the benefits detailed here: Benefits

Relocation benefits are available.

Who we are

A healthier future drives us to innovate. Over 100,000 employees worldwide are dedicated to advancing science, ensuring access to healthcare today and for future generations. Our efforts have resulted in over 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep high ambitions to deliver life-changing healthcare solutions with a global impact.

Let's build a healthier future, together.

Roche is an equal opportunity employer. It is our policy to employ, promote, and treat all employees and applicants based on merit, qualifications, and competence. Discrimination based on protected veteran status, disability, or other protected categories is prohibited.

If you need accommodations for the online application process, please contact us through the Accommodations for Applicants form.