Senior Scientist

Scorpion Therapeutics; Princeton (NJ); On-site; USD 110,000 - 160,000; Full time

Job summary

Scorpion Therapeutics in Princeton, NJ, seeks an experienced ADME-focused scientist to drive in vitro ADME assays and metabolism studies across discovery and development compounds.

The role involves experimental design, data interpretation, and mentoring junior scientists, in a fast-paced environment with multi-project responsibility. Strong LC-MS/MS and bioanalytical skills are essential.

Qualifications

• PhD in a scientific relevant field (Ph.D. preferred) with experience in contract research organizations, pharmaceutical industries, or academia; OR Master’s with 6+ years of experience.
• Equivalent education and experience acceptable.
• Industry/academic experience in DM/PK with a strong record of scientific achievement.
• Experience in drug discovery/development.
• Broad understanding of ADME, in vitro drug metabolism, and DDI.
• Knowledge of bioanalytical sciences including LC-MS/MS, GC-MS, biotransformation, and physical organic chemistry.
• Experience with cell-based or biochemical assays.
• Excellent oral and written communication; strong attention to detail.
• Proficiency with Microsoft Word and Outlook.
• Ability to manage time and work independently; communicate with peers and all levels of management.

Responsibilities

• Conduct routine in-vitro ADME assays.
• Plan, perform, and report in vitro metabolism ADME studies for discovery and development stage compounds.
• Participate in experimental design; perform experiments; critically analyze, interpret, and report data to define next steps.
• Complete high-impact and high-throughput studies in a fast-paced environment while managing multiple projects to meet timelines.
• Establish new ADME assays and contribute to continuous improvement of existing assays.
• Guide junior scientists.
• Assist with data analysis and interpretation.
• Provide laboratory support (ordering, equipment calibration/validation) while adhering to the Quality System.
• Work with Project Managers to meet client requirements.
• Assist in running and maintaining robotic systems.
• Perform quality review of peer data; help consolidate assay control and validation criteria.
• Perform other duties as assigned.

Skills

ADME understanding

LC-MS/MS

Biotransformation

Project management

Scientific writing

Team leadership

Communication

Education

PhD in a scientific field

MS in a relevant field

Tools

LC-MS/MS instrumentation

GC-MS instrumentation

Bioanalytical software

Laboratory automation

Job description

Responsibilities:

• Conduct routine in-vitro ADME assays.


• Plan, perform, and report in vitro metabolism ADME studies for discovery and development stage compounds.


• Participate in experimental design; perform experiments; critically analyze, interpret, and report data to define next steps.


• Complete high-impact and high-throughput studies in a fast-paced environment while managing multiple projects to meet timelines.


• Establish new ADME assays and contribute to continuous improvement of existing assays.


• Guide junior scientists.


• Assist with data analysis and interpretation.


• Provide laboratory support (ordering, equipment calibration/validation) while adhering to the Quality System.


• Work with Project Managers to meet client requirements.


• Assist in running and maintaining robotic systems.


• Perform quality review of peer data; help consolidate assay control and validation criteria.


• Perform other duties as assigned.

Qualifications:

• PhD in a scientific relevant field (Ph.D. preferred) with experience in contract research organizations, pharmaceutical industries, or academia; OR Master’s with 6+ years of experience.


• Equivalent education and experience acceptable.


• Industry/academic experience in DM/PK with a strong record of scientific achievement.


• Experience in drug discovery/development.


• Broad understanding of ADME, in vitro drug metabolism, and DDI.


• Knowledge of bioanalytical sciences including LC-MS/MS, GC-MS, biotransformation, and physical organic chemistry.


• Experience with cell-based or biochemical assays.


• Excellent oral and written communication; strong attention to detail.


• Proficiency with Microsoft Word and Outlook.


• Ability to manage time and work independently; communicate with peers and all levels of management.

Desirable:

• Plate-based screening; cell culture experience; LC-MS/MS experience.