Senior Scientist

Advanced Regenerative Manufacturing Institute (ARMI) | BioFabUSA; Manchester (NH); On-site; USD 90,000 - 130,000; Full time

Job summary

ARMI BioFabUSA is seeking a highly motivated scientist to join our Multi-Omics group to develop and apply state-of-the-art methodologies to interrogate small molecule signatures within our bioprocesses.

The successful candidate will lead untargeted metabolomics and lipidomics analyses, coordinate sample handling and LC-MS workflows, and collaborate across Process Development and Data Science to translate findings into actionable biological insights.

Qualifications

• Experience in untargeted metabolomics and/or lipidomics.
• Hands-on LC-MS analysis and data processing.
• Experience with automation and high-throughput workflows.
• Strong communication and collaboration skills.

Responsibilities

• Develop an optimized untargeted analysis pipeline for polar metabolites and lipids.
• Prepare bioreactor samples for LC-MS analysis with automation.
• Operate and maintain Thermo LC-MS instruments.
• Analyze LC-MS data with Compound Discoverer, LipidSearch, MZmine, Python/R.
• Collaborate with multi-omics and other groups to extract insights.
• Ensure adherence to safety and quality SOPs.

Skills

Untargeted metabolomics

Lipidomics

LC-MS operation

Automation

Data analysis (Python/R)

Communication

Education

MS in Chemistry/Biochemistry/Biotechnology

PhD in a related field

Tools

Thermo LC‑MS systems (Vanquish UHPLC, Exploris 480, IQ-X)

Compound Discoverer

LipidSearch

MZmine

Python

R

Job description

The Advanced Regenerative Manufacturing Institute (ARMi) BioFabUSA is a Member-based non‑profit, member‑driven, public‑private partnership with a mission to advance the bioeconomy and transform the future of human health. ARMI provides technical and wrap‑around commercialization services to companies seeking to advance technologies that will contribute to this impact.

The Impact That You Will Make

ARMI is seeking a highly motivated scientist to join our growing Multi‑Omics group to develop and apply state‑of‑the‑art methodologies to interrogate small molecule signatures within our bioprocesses. The successful candidate will spearhead efforts to characterize metabolomics and lipidomics profiles across processes in manufacturing cell‑based therapy products, collaborating across groups for multi‑omic analysis. The ideal candidate will have demonstrated expertise in untargeted metabolomics and/or lipidomics and extensive hands‑on experience with sample handling automation, LC‑MS instrumentation, and data analysis software platforms.

Your Role

• Develop an optimized pipeline for deep, untargeted analysis of polar metabolites and lipids from bioreactor cultured cells and conditioned media.
• Prepare bioreactor samples for liquid chromatography‑mass spectrometry analysis, leveraging automation for improved throughput.
• Operate and maintain Thermo LC‑MS instrumentation, including Vanquish UHPLC, Exploris 480, and IQ‑X.
• Analyze LC‑MS raw data with processing software including Compound Discoverer, LipidSearch, MZmine, and Python/R scripting.
• Collaborate closely within the Multi‑Omics group and across Process Development and Data Science groups to discover and communicate biological insights that will deliver impact.
• Engage with Operations Support, service engineers, and vendors for instrument maintenance, optimization, and upgrades.
• Adhere to safety and quality guidelines and SOPs.

Your Skills And Experiences

• Degree in Chemistry, Biochemistry, Biotechnology or related area. MS with 5-10 years of experience or PhD with 2-5 years postgraduate experience.
• Significant hands‑on experience across all stages of untargeted small molecule analyses: sample preparation, mass spectrometric analyses, and data processing and interpretation.
• Familiarity with lab automation and higher‑throughput workflows. Experience with Biomek systems is a plus.
• Good communication skills, proactive attitude, and results‑driven mindset.

Work Environment & Schedule Expectations

• Work in a laboratory environment with exposure to biological materials, chemical reagents, and analytical instrumentation.
• Ability to stand for extended periods and safely operate laboratory equipment.
• Occasional work outside of regular business hours, including evening, weekend, or overtime work may be required to support critical project timelines and business needs.
• Limited travel may be required for conferences, training, or client meetings.

By applying, I understand that any offer of employment is contingent upon the successful completion of a background check, in accordance with applicable laws.