Senior Scientist

ALOIS Solutions; Emeryville (CA); On-site; USD 90,000 - 120,000; Full time

Job summary

ALOIS Solutions in Emeryville, CA is seeking a hands-on in vitro ADME Scientist for an 18-month position with potential extension. You will design and execute ADME assays, analyze data, and report findings to support drug discovery and candidate progression.

The role requires 2+ years in vitro ADME experience, LC-MS/MS proficiency (Sciex preferred), and comfort with automation platforms and ELN documentation. On-site work in California with a collaborative team environment.

Qualifications

• BS or MS in chemistry, biochemistry, pharmacology, pharmaceutical sciences, biology, or a related scientific discipline.
• Minimum of 2 years of hands-on in vitro ADME experience in a biopharmaceutical, pharmaceutical, or contract research organization environment.
• Strong understanding of DMPK and ADME principles, including assay design, data analysis, and interpretation.
• Demonstrated experience designing and executing automated in vitro assays to evaluate and optimize ADME properties of drug candidates.
• Hands-on experience with LC-MS/MS-based sample analysis; experience with Sciex instruments is preferred.
• Proficiency with data analysis and visualization tools such as Microsoft Excel, GraphPad Prism, Analyst, or similar software.
• Experience using electronic laboratory notebooks.
• Experience with laboratory automation platforms such as Hamilton, Tecan, or similar systems is preferred.

Responsibilities

• Design, develop, and execute in vitro ADME assays to support drug discovery and candidate optimization.
• Conduct ADME screening studies, including microsomal stability, hepatocyte stability, permeability, plasma protein binding, and related metabolism assays.
• Generate, analyze, interpret, and report high-quality data to support project decisions and compound progression.
• Design and troubleshoot in vitro experiments to address project-specific questions related to compound metabolism, stability, permeability, and protein binding.
• Contribute to LC-MS/MS bioanalytical method development, sample analysis, assay optimization, and troubleshooting.
• Apply enzyme kinetic and quantitative bioanalytical principles to support assay design and data interpretation.
• Maintain accurate documentation in electronic laboratory notebooks and ensure adherence to internal quality and safety standards.
• Support implementation and use of laboratory automation platforms, as applicable.

Skills

ADME principles

DMPK

LC-MS/MS

Automated in vitro assays

Data analysis

Electronic lab notebooks

Lab automation

Excel/Prism

Education

BS or MS in chemistry/biochemistry/pharmacology/pharmaceutical sciences/biology

Tools

LC-MS/MS (Sciex)

GraphPad Prism

Analyst

Job description

Duration: 18 Months (High Possibility of Extension)

Responsibilities

• Design, develop, and execute in vitro ADME assays to support drug discovery and candidate optimization.
• Conduct ADME screening studies, including but not limited to microsomal stability, hepatocyte stability, permeability, plasma protein binding, and related metabolism assays.
• Generate, analyze, interpret, and report high-quality data to support project decisions and compound progression.
• Design and troubleshoot in vitro experiments to address project-specific questions related to compound metabolism, stability, permeability, and protein binding.
• Contribute to LC-MS/MS bioanalytical method development, sample analysis, assay optimization, and troubleshooting.
• Apply enzyme kinetic and quantitative bioanalytical principles to support assay design and data interpretation.
• Maintain accurate documentation in electronic laboratory notebooks and ensure adherence to internal quality and safety standards.
• Support implementation and use of laboratory automation platforms, as applicable.

Qualifications

• BS or MS in chemistry, biochemistry, pharmacology, pharmaceutical sciences, biology, or a related scientific discipline.
• Minimum of 2 years of relevant hands-on in vitro ADME experience in a biopharmaceutical, pharmaceutical, or contract research organization environment.
• Strong understanding of DMPK and ADME principles, including assay design, data analysis, and interpretation.
• Demonstrated experience designing and executing automated in vitro assays to evaluate and optimize ADME properties of drug candidates.
• Hands-on experience with LC-MS/MS-based sample analysis; experience with Sciex instruments is preferred.
• Proficiency with data analysis and visualization tools such as Microsoft Excel, GraphPad Prism, Analyst, or similar software.
• Experience using electronic laboratory notebooks.
• Experience with laboratory automation platforms such as Hamilton, Tecan, or similar systems is preferred.