Senior Research Chemist - Drug Discovery

Placements24; Waukee (IA); On-site; USD 55,000 - 73,000; Full time

Benefits offered by this job

Competitive salary

Medical, dental, and vision insurance

Generous paid time off

Job summary

Placements24 is seeking a Senior Research Chemist for a drug discovery team in Paarl. The role focuses on designing and synthesizing novel small molecules, optimizing lead compounds, and contributing to SAR studies in a state-of-the-art laboratory.

You will work closely with biologists and pharmacologists to advance candidates through the discovery pipeline, document procedures, and contribute to scientific reports and patent filings.

Qualifications

• Ph.D. in Organic Chemistry or Medicinal Chemistry required.
• Minimum 5 years of relevant experience in synthetic organic chemistry.
• Proven expertise in synthetic route design and troubleshooting.
• Proficiency with analytical techniques for compound characterization.
• Strong problem-solving and collaborative abilities.

Responsibilities

• Design and synthesize novel small molecules for drug discovery programs.
• Purify and characterize compounds using NMR, LC-MS, and HPLC.
• Conduct SAR studies in collaboration with medicinal chemists and biologists.
• Optimize lead compounds for potency, selectivity, and PK properties.
• Maintain meticulous records and contribute to reports and patent filings.

Job description

Our client is seeking a highly skilled Senior Research Chemist to join their dedicated drug discovery team in Paarl . This pivotal role involves the synthesis and optimization of novel small molecules with therapeutic potential. You will be at the forefront of medicinal chemistry efforts, designing and executing synthetic routes, characterizing compounds, and contributing to structure-activity relationship (SAR) studies. Working within a state-of-the-art laboratory, you will collaborate with biologists and pharmacologists to advance drug candidates through the discovery pipeline. This is an exceptional opportunity for an experienced chemist to make a significant impact on the development of life-saving medicines in Paarl .

Key Responsibilities

• Design and synthesize novel small molecules for drug discovery programs, employing modern synthetic organic chemistry techniques.
• Purify and characterize synthesized compounds using a range of analytical methods, including NMR , LC-MS, and HPLC.
• Conduct structure-activity relationship (SAR) studies in collaboration with medicinal chemists and biologists.
• Optimize lead compounds for improved potency, selectivity, and pharmacokinetic properties.
• Maintain meticulous records of experimental procedures and results, and contribute to scientific reports and patent filings.

Requirements

• Ph.D. in Organic Chemistry, Medicinal Chemistry, or a related field.
• Minimum of 5 years of relevant experience in synthetic organic chemistry, preferably within the pharmaceutical industry.
• Demonstrated expertise in synthetic route design, execution, and troubleshooting.
• Proficiency with standard laboratory equipment and analytical techniques for compound characterization.
• Strong problem-solving skills and the ability to work independently and collaboratively in a fast-paced research environment.

Benefits

• Competitive salary and performance-based incentives.
• Comprehensive medical, dental, and vision insurance.
• Generous paid time off and company holidays.
• Opportunities for professional development and advancement within the R&D organization.
• A stimulating and collaborative research environment in Paarl , focused on innovation.