Senior Research Biostatistics Lead - Strategy & Analytics

BioSpace; Waltham (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

CSL Behring invites a seasoned Associate Director, Research Biostatistics to lead strategic statistical initiatives across discovery, translational, and early development programs. The role blends hands-on study design with innovative methodology and evidence-generation strategies to support portfolio progression.

The successful candidate will drive advanced analyses, mentor teams, and collaborate with Translational Bioinformatics, Global Biometrics, and PK/PD to deliver high-quality scientific

Qualifications

• PhD in Statistics, Biostatistics, or equivalent experience.
• 8+ years applying statistics in pre-clinical pharmaceutical, biotechnology, healthcare, or biomedical research environment.
• Demonstrated track record in developing and applying advanced statistical methodologies for biological, translational, biomarker, omics, imaging, or related data.
• Proven experience with modern statistical programming, reproducible analysis workflows, and quantitative computing platforms, particularly R and related technologies.
• Evidence of scientific contribution through publications or development of analytical tools and platforms.

Responsibilities

• Provide strategic statistical leadership across discovery, translational, and early research programs, ensuring robust study design, analysis, interpretation, and project decision support.
• Lead and perform complex statistical analyses across preclinical, translational, biomarker, imaging, omics, and human research datasets using advanced methodologies such as Bayesian methods, causal inference, longitudinal modelling, and machine learning.
• Develop and apply innovative statistical methods, reproducible analytical workflows, and statistical programming solutions, particularly in R and related platforms.
• Support biomarker identification, evaluation, and validation activities, contributing to translational evidence-generation strategies that strengthen research and portfolio decisions.
• Translate complex scientific data into actionable insights that support target evaluation, candidate selection, project progression, portfolio prioritisation, and probability-of-success assessments.
• Collaborate with Translational Bioinformatics, Global Biometrics, Data Management, PK/PD, and other quantitative functions, applying state-of-the-art statistical methodologies to address scientific challenges.
• Contribute to scientific publications, ethics submissions, external collaborations, and scientific communications.
• Mentor and develop statisticians, scientists, contractors, and interns, providing scientific leadership and fostering a culture of excellence, collaboration, and continuous learning.
• Champion data-driven decision making, promote statistical best practices, and deliver training to strengthen analytical capability across the organisation.
• Establish and manage relationships with external collaborators, academic partners, CROs, consultants, and technology providers, ensuring delivery of high-quality scientific outcomes.

Skills

Bayesian methods

Causal inference

Longitudinal modelling

Machine learning

Statistical leadership

Education

PhD in Statistics/Biostatistics

Tools

R

Job description

CSL Behring invites a seasoned Associate Director, Research Biostatistics to lead strategic statistical initiatives across discovery, translational, and early development programs. The role blends hands-on study design with innovative methodology and evidence-generation strategies to support portfolio progression.

The successful candidate will drive advanced analyses, mentor teams, and collaborate with Translational Bioinformatics, Global Biometrics, and PK/PD to deliver high-quality scientific