Senior Research Associate (Stem Cell)

Piper Companies; Cambridge (MA); On-site; USD 70,000 - 100,000; Full time

Benefits offered by this job

Medical benefits

Dental & Vision benefits

401k

Paid Holidays & PTO

Job summary

Piper Companies is seeking a highly motivated Senior Research Associate II to support the development of innovative cell-based therapies. This role will contribute to stem cell research, genetic engineering studies, and translational biology programs through hands-on laboratory experimentation and data analysis.

Based at our Cambridge, MA site, you will perform culture and differentiation of human stem cells, support cellular engineering efforts, monitor cell health, and carry out molecular

Qualifications

• 3+ years of hands-on human pluripotent stem cell culture experience.
• Experience in regenerative medicine, cell therapy or related therapeutic development.
• GMP-regulated biotech/biopharmaceutical environment experience.
• Experience with flow cytometry, RT-qPCR, ddPCR, ELISA and immunostaining.

Responsibilities

• Culture, expand, maintain, and differentiate human stem cells and other mammalian cell lines.
• Support cellular engineering, gene modification, and functional evaluation.
• Monitor cell health, sterility, and record keeping.
• Perform molecular biology techniques including nucleic acid extraction and cDNA prep.
• Conduct assays such as flow cytometry, qPCR, ddPCR, ELISA, and immunostaining.
• Develop and troubleshoot experimental workflows and SOPs.
• Compile and present data using appropriate statistics.
• Manage laboratory inventory and purchasing.

Skills

Stem cell culture

GMP experience

Flow cytometry

RT-qPCR

ddPCR

ELISA

Immunostaining

qPCR

Immunofluorescence

Data analysis

Education

Bachelor's or Master's degree in Biology or related field

Job description

Piper Companies is seeking a highly motivated Senior Research Associate II to support the development of innovative cell-based therapies. This role will contribute to stem cell research, genetic engineering studies, and translational biology programs through hands-on laboratory experimentation and data analysis. This role is out of Cambridge, MA.

Responsibilities of the Senior RA II:

• Perform routine culture, expansion, maintenance, and differentiation of human stem cells and other mammalian cell lines.
• Support research initiatives involving cellular engineering, gene modification, and evaluation of cellular function in both laboratory and preclinical settings.
• Monitor cell health, growth characteristics, sterility, and experimental quality while maintaining detailed laboratory records.
• Carry out molecular and cellular biology techniques, including nucleic acid extraction, cDNA preparation, gene expression analysis, and protein-based assays.
• Conduct experiments using technologies such as flow cytometry, quantitative PCR, digital PCR, ELISA, immunofluorescence, and related analytical methods.
• Assist in developing, optimizing, and troubleshooting experimental workflows and standard operating procedures.
• Compile, interpret, and present experimental findings using appropriate statistical and analytical methods.
• Maintain laboratory inventory, prepare reagents, monitor supplies, and coordinate purchasing of laboratory materials and equipment.

Qualifications of the Senior RA II:

• 3+ years of hands-on experience with human pluripotent stem cell culture (IPSC), differentiation, and maintenance
• Experience in regenerative medicine, cell therapy, gene editing, or related therapeutic development fields.
• Must have experience working in a GMP-regulated biotech/biopharmaceutical environment
• Extensive experience performing techniques such as flow cytometry, RT-qPCR, ddPCR, ELISA, and immunostaining methods.
• Bachelor's or Master's degree in Biology, Cell Biology, Molecular Biology, Biotechnology, Regenerative Medicine, Genetics, or a related scientific discipline
• Schedule requires weekend work – 40 hours per week (Thurs-Monday Shift or Fri-Tues)

Compensation for the Senior RA II:

• Salary: $70,000 - $100,000, commensurate with experience
• Comprehensive Benefits: Medical, Dental, Vision 401k, Paid Holidays, PTO (Paid Time Off), Sick leave required as by law

This job opens for applications on 8/12/2026. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords:

Research Associate, Scientist, Senior Research Associate, RA, IPSC, Human Pluripotent, Stem Cell, Cell Culture, Cell Therapy, Regenerative Medicine, Gene Editing, GMP, Good Manufacturing Practice, Pharma, Biotech, Immunostaining, RT-qPCR, qPCR, ddPCR, ELISA, Western Blot, Immunology, Molecular Biology, DNA, RNA, Cell Biology, Associate Scientist, Cellular Engineering, Flow Cytometry, Immunohistochemistry, 3D, 2D, Immunofluorescence, Staining, Aseptic Technique, Process Development, Genetic Engineering, Differentiation, Tissue Culture, Human Stem, Induced Pluripotent Stem Cell, CHO, Pluripotent, Emrbyonic, Immune Cell, Heart cell, Pancreatic Cell, Kidney Cell, Liver Cell, Disease Modeling

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