Senior Research Associate, Protein Expression & Purification

Zachary Piper Solutions; Cambridge (MA); On-site; USD 76,000 - 90,000; Full time

Benefits offered by this job

Medical, Dental, Vision

Sick leave

401K

Job summary

Piper Companies is seeking a Senior Research Associate, Protein Expression & Purification to join an innovative biotechnology organization supporting immunology research in Cambridge, MA. This onsite 6-12 month contract will involve generating and purifying recombinant proteins and collaborating closely with lab teams.

You will use ÄKTA/FPLC systems, maintain detailed records, and support project milestones with rigorous documentation and quality control.

Qualifications

• Bachelor’s or Master’s degree in Biochemistry, Molecular Biology, Biotechnology, Protein Sciences, or a related scientific field.
• 2–5 years of hands‑on protein expression, purification, or related laboratory research experience.
• Experience with chromatography systems such as ÄKTA or FPLC.
• Experience purifying proteins from inclusion bodies; strong documentation and organization.

Responsibilities

• Conduct recombinant protein production and purification using chromatography-based workflows.
• Isolate, recover, and refine proteins from various expression systems.
• Utilize ÄKTA, FPLC, or comparable purification platforms to support research objectives.
• Maintain detailed experimental records and document findings in electronic lab systems.
• Collaborate with scientists and cross‑functional teams to deliver protein materials and support milestones.

Skills

Protein expression

Protein purification

Lab documentation

Team collaboration

Education

Biochemistry / Molecular Biology degree

Tools

ÄKTA

FPLC

Job description

Piper Companies is seeking a Senior Research Associate, Protein Expression & Purification to join an innovative biotechnology organization supporting advanced immunology research for a 6-12 month onsite contract position based out of Cambridge, Massachusetts. The Senior Research Associate, Protein Expression & Purification will play a key role in generating and purifying recombinant proteins for research programs, while working closely with laboratory teams to ensure high-quality scientific outputs and timely project support. This is a contract opportunity with an anticipated duration of 6-12 months.

Responsibilities of the Senior Research Associate, Protein Expression & Purification include:

• Conduct recombinant protein production and purification activities using chromatography-based workflows and related laboratory equipment.
• Isolate, recover, and refine proteins from a variety of expression systems, including challenging protein formats.
• Utilize ÄKTA, FPLC, or comparable purification platforms to support research and development objectives.
• Maintain detailed experimental records and accurately document findings within electronic laboratory systems.
• Partner with scientists and cross-functional research teams to deliver protein materials and support program milestones.

Qualifications for the Senior Research Associate, Protein Expression & Purification include:

• Bachelor’s or Master’s degree in Biochemistry, Molecular Biology, Biotechnology, Protein Sciences, or a related scientific field.
• 2-5 years of hands‑on experience in protein expression, purification, or related laboratory research environments.
• Demonstrated expertise working with chromatography systems such as ÄKTA or FPLC.
• Experience recovering and purifying proteins from inclusion bodies and performing basic protein analysis.
• Strong organizational, communication, and documentation skills with the ability to independently execute established laboratory procedures.

Compensation for the Senior Research Associate, Protein Expression & Purification:

Salary Range: $55-$65/hr (USD)

Comprehensive Benefits: Medical, Dental, Vision, sick leave if required by law, and 401K

This job opens for applications on 10/2/26. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords: protein expression, protein purification, recombinant proteins, chromatography, ÄKTA, FPLC, protein sciences, biochemistry, molecular biology, biotechnology, inclusion bodies, immunology, cytokines, receptors, cell culture, protein characterization, mass spectrometry, laboratory research, ELN, scientific documentation, protein production, quality control, laboratory operations, R&D, biologics, biotherapeutics, purification workflows, analytical techniques, life sciences, biotechnology research.

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