Senior Research Associate, High-Throughput RNA Production

Sail Biomedicines; Cambridge (MA); On-site; USD 75,000 - 95,000; Full time

Job summary

Sail Biomedicines is seeking a Senior Research Associate for high-throughput RNA production to advance Endless RNA™ technology. You will perform end-to-end RNA generation from template cloning to IVT, manage materials, and help optimize workflows in a fast-paced environment.

The role emphasizes meticulous documentation, teamwork, and strong problem-solving to support real-world patient impact, with a competitive salary and benefits package.

Qualifications

• B.S. in Life Sciences, Chemistry, Engineering, or a related field with 2+ years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
• Ability to manage multiple tasks at once efficiently
• Strong collaborative spirit and communication skills
• Excellent record keeping
• Experience with RNA production and purification is preferred
• Experience with automated liquid handling systems and high-throughput workflows is preferred

Responsibilities

• Perform high-throughput cloning of plasmid constructs and RNA generation through in vitro transcription (IVT)
• Determine circularization efficiency and impurity levels by running analytic assays
• Coordinate DNA synthesis and scale-up orders with external vendors
• Manage raw material and RNA inventories
• Collaborate with automation engineer to improve process workflow
• Maintain detailed documentation in electronic lab notebooks
• Present findings clearly to platform teams and contribute to scientific discussions and decision-making

Skills

Task management

Collaboration & communication

Documentation skills

Education

B.S./M.S. in Life Sciences/related field

Tools

Excel

Benchling

SnapGene

Graphic Prism

HPLC

Hamilton (automation)

Job description

About Sail

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

About Sail

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role

The Senior Research Associate, high-throughput (HTP) RNA production, serves an important role in generating RNAs to advance Sail’s first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role will carry out end-to-end process of high-throughput RNA production, from template plasmid cloning to RNA generation and clean up. The successful candidate is organized, attentive to details, a fast learner with a strong sense of responsibility who takes pride in his/her work. The team looks forward to helping you strive in this exciting and fast-paced environment to make a real-world impact on patients’ lives.

Responsibilities

• Perform high-throughput cloning of plasmid constructs and RNA generation through in vitro transcription (IVT)
• Determine circularization efficiency and impurity levels by running analytic assays
• Coordinate DNA synthesis and scale-up orders with external vendors
• Manage raw material and RNA inventories
• Collaborate with automation engineer to improve process workflow
• Maintain detailed documentation in electronic lab notebooks
• Present findings clearly to platform teams and contribute to scientific discussions and decision-making

Qualifications

• B.S. in Life Sciences, Chemistry, Engineering, or a related field with 2+ years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
• Ability to manage multiple tasks at once efficiently
• Strong collaborative spirit and communication skills
• Excellent record keeping

Preferred Qualifications

• Experience in molecular biology including cloning, RNA production and purification
• Familiarity with high-performance liquid chromatography (HPLC) or other column-based purification/analytic methods
• Experience with automated liquid handling systems (e.g., Hamilton) and high-throughput laboratory workflows
• Experience using data analysis and information management tools, such as Excel, Graphic Prism, SnapGene, Benchling
• Experience in inventory management

Salary Range:

$75,000 - $95,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.