Scientist, Platform RNA Sciences New Cambridge, MA

Sail Biomedicines, Inc.; Cambridge (MA); On-site; USD 98,000 - 125,000; Full time

Job summary

Sail Biomedicines, Inc. seeks a Scientist, Platform RNA Sciences, to advance its programmable circular RNA technology (Endless RNA). You will perform hypothesis-driven experiments and high-throughput screens to optimize circularization, RNA stability, and translation in a fast-paced, collaborative environment.

The role emphasizes independent experiment design, data analysis, and clear communication of results to stakeholders, contributing to real-world patient impact.

Qualifications

• PhD or MS with substantial RNA research experience.
• Strong background in RNA biology and related techniques.
• Experience with high-throughput screening and data analysis.
• Proficient in using common data management tools.

Responsibilities

• Conceive and conduct screens to improve eRNA designs and product purity.
• Design hypothesis-driven experiments using state-of-the-art RNA biology.
• Evaluate and develop alternative circularization strategies.
• Determine circularization efficiency and impurity levels via analytic assays.
• Maintain detailed documentation and generate technical reports.
• Present findings clearly to internal and external stakeholders.

Skills

Analytical thinking

Problem-solving

Multitasking

Communication

Collaboration

Education

Ph.D. in Molecular Biology, Biochemistry, or a related field

M.S. with 6+ years of focused RNA research

Tools

Excel

Graphic Prism

R

JMP

SnapGene

Benchling

Smartsheet

Jira

Job description

The Role

The Scientist, Platform RNA Sciences, will work on key projects to advance Sail’s first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role works cross-functionally to perform hypothesis-driven experiments and high-throughput screens to improve our eRNA designs, with the goal to maximize circularization, and enhance RNA stability and translation. The successful candidate is self-motivated, curious and creative, thinks outside of the box and has a can-do mindset. The team looks forward to helping you strive in this exciting and fast-paced environment to make a real-world impact on patients’ lives.

Responsibilities

• Conceive and conduct pooled and array screens to improve our eRNA designs, enabling higher product purity and function
• Design hypothesis-driven experiments based on state-of-the-art RNA biology to refine our eRNA designs
• Evaluate and develop alternative circularization strategies
• Determine circularization efficiency and impurity levels by running analytic assays
• Design properly controlled experiments, generate high-quality data, and run rigorous statistical analysis
• Maintain detailed documentation in electronic lab notebooks
• Author standard operating procedures (SOPs), study summaries, and technical reports
• Present findings clearly in oral or written formats to internal and external stakeholders to enable alignment and decision-making

Qualifications

• Ph.D. in Molecular Biology, Biochemistry, or a related field, or M.S. with 6+ years of focused, full-time research experience in RNA technologies
• Strong background in RNA biology with demonstrated skillset in relevant molecular and biochemical techniques, such as in vitro transcription (IVT), RNA purification, oligo-dT purification, column chromatography, capillary gel electrophoresis, RT-qPCR, RNA-seq, Nanopore sequencing
• Experience using data analysis and information management tools such as Excel, Graphic Prism, R, JMP, SnapGene, Benchling, Smartsheet, Jira
• Excellent problem-solving skills with the ability to independently design and carry out experiments
• Ability to manage multiple tasks at once while knowing how to prioritize
• Strong collaborative spirit and excellent organizational and communication skills

Preferred Qualifications

• Experience in Next Generation Sequencing (NGS) library preparation
• Working knowledge in engineering ribozyme, aptamer or other complex RNA structures

Salary Range: $98,000 - $125,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.