Senior Research Associate, Flow Cytometry

Beam Therapeutics Inc.; Cambridge (MA); On-site; USD 95,000 - 115,000; Full time

Job summary

Beam Therapeutics is seeking a hands-on flow cytometry scientist in Cambridge, MA to support internal and external research programs. You will perform specimen preparation, staining, and sample acquisition, operate high-parameter flow cytometers, and contribute to assay and platform development within the core flow cytometry group.

The role emphasizes data analysis, instrument troubleshooting, and knowledge transfer, with no telecommuting and on-site work at Beam's Cambridge site.

Qualifications

• Bachelor’s degree (or foreign equivalent) with five years of progressive, post-baccalaureate experience, or a master’s degree (or foreign equivalent) with two years of progressive, post-baccalaureate experience, in biology, immunology, or related field.
• Experience performing high-parameter flow cytometry analyses of hematopoietic stem and immune cell subsets.
• Design and execute flow-based assay development for preclinical or translational research.
• Quantitative flow cytometry data analysis using FlowJo or FCS Express.
• Troubleshooting instrument performance and coordinating maintenance; operating high-parameter flow cytometers and cell sorters.

Responsibilities

• Supporting all internal/external research programs.
• Execute specimen preparation, staining and sample acquisition of flow cytometric data.
• Perform cell sorting on BD FACS Melody, FACSAria Fusion or BD FACS Symphony S6.
• Design, plan, and execute assay development and/or platform development within the core flow cytometry group and cross-functionally.
• Perform flow data analyses and interpretation, and present data at group meetings.

Skills

Flow cytometry

Data analysis

Cell sorting

Assay development

Preclinical research

Education

Bachelor’s degree with 5+ years or Master’s with 2+ years in biology or related field

Tools

FlowJo

FCS Express

BD FACS Melody

FACSAria Fusion

BD FACS Symphony S6

Job description

Company Overview:

Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform with integrated gene editing, delivery and internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.

Primary Responsibilities:

• Supporting all internal/external research programs.
• Execute specimen preparation, staining and sample acquisition of flow cytometric data.
• Perform cell sorting on BD FACS Melody, FACSAria Fusion or BD FACS Symphony S6.
• Design, plan, and execute assay development and/or platform development within the core flow cytometry group and cross-functionally.
• Perform flow data analyses and interpretation, and present data at group meetings.
• Maintain electronic notebook record of performed experiments.
• Provide basic training to researcher on various flow cytometers and cell sorters.
• Evaluate and troubleshoot instrument issues.
• Assist in coordinating core lab logistics (e.g. user scheduling, vendor/maintenance calls, etc.)

Qualifications:

• Bachelor’s degree (or foreign equivalent) with five years of progressive, post-baccalaureate experience, or a master’s degree (or foreign equivalent) with two years of progressive, post-baccalaureate experience, with degree fields in biology, immunology, cell biology, molecular biology, pharmaceutical sciences, biochemistry, biomedical engineering, biotechnology or a closely related field, and demonstrated experience in all of the following:

(a) performing high-parameter flow cytometry analyses of hematopoietic stem and immune cell subsets, and,

(b) designing and executing flow-based assay development for preclinical or translational research; and,

(c) conducting quantitative flow cytometry data analysis using FlowJo or FCS Express; and,

(d) troubleshooting instrument performance and coordinating maintenance; and,

(e) operating and maintaining high-parameter flow cytometers and cell sorters.

Other Information:

• Permanent, full-time, immediately available, job opportunity;

• Does not require travel (role is substantially laboratory-based, in-house);

• Not permitted to telecommute, i.e., cannot exclusively work remotely from home;

• Must live in the City of Cambridge, MA, or within a reasonable, daily commuting distance thereof (e.g., areas contemplated can include the City of Boston, the larger Greater Boston region, or Massachusetts’ MetroWest, North or South Shore communities);

• Beam’s headquarters is at 238 Main Street, Cambridge, MA 02142 and this is the primary worksite for the role long-term; and

• Role is not a supervisory role and does not have subordinate, direct reports. This is a hands-on, individual contributor position.

Salary Range

$95,000—$115,000 USD