Senior Research Associate, Analytical Development

Janux Therapeutics; California (MO); On-site; USD 95,000 - 108,000; Full time

Benefits offered by this job

Annual bonus program

Stock options

Restricted stock units

Stock purchase plan (ESPP)

Medical insurance

Dental insurance

Vision insurance

HSA / FSA

Unlimited PTO

Relocation assistance

Job summary

Janux Therapeutics in San Diego, CA is seeking a Senior Research Associate to design and execute experiments and analyze samples using HPLC, CE-SDS, iCIEF, and plate-based assays to support CMC, discovery, and early clinical development.

This hands-on role requires meticulous documentation, collaboration with team leaders, and the ability to communicate results for regulatory filings and future clinical candidates.

Qualifications

• Bachelor’s degree with 4–6 years of experience or Master’s with 3–5 years in industry.
• Strong bench skills and experience with protein biologics and peptides.
• Proficient with HPLC/UPLC; SEC and RP preferred.
• Experience with CE-SDS, iCIEF or similar electrophoretic methods.
• Experience performing ELISAs is desirable.
• Experience supporting analytical method qualification, stability, and formulation studies.
• Ability to analyze complex datasets and communicate conclusions.
• Excellent computer skills, especially Excel and PowerPoint.

Responsibilities

• Perform HPLC/UPLC assays including SEC/RP with minimal supervision.
• Execute CE-SDS and iCIEF analyses for protein therapeutics and qualify methods.
• Conduct ELISAs for potency and DLS/SLS with UNcle for formulation studies.
• Perform subvisible particulate analysis by HIAC and support stability studies.
• Design, conduct, and report experiments; summarize results for meetings/regulatory filings.
• Write and manage SOPs and test methods; maintain reagents and lab equipment.
• Draft development reports, method qualification protocols and reports.
• Prepare team presentations and work with leaders to hit milestones.
• Possibly train others and maintain GDP-compliant documentation.

Skills

HPLC analysis

UPLC analysis

CE-SDS

iCIEF

ELISA

DLS/SLS

Data analysis

GDP compliance

Excel

PowerPoint

Education

Bachelor’s degree in related field

Master’s degree with 3–5 years in relevant industry

Tools

UNcle instrument

SOP writing tools

Job description

Our Analytical Development team is growing and we’re seeking a Senior Research Associate to participate in designing and executing experiments, as well as perform sample analysis utilizing HPLC, CE-SDS, iCIEF, and plate-based assays. These activities will support CMC, discovery, pre-clinical, and clinical development of existing and new lead candidates. This position will directly support the discovery of next‑generation immune oncology drugs. It is a hands‑on position that requires effective communication and documentation of results to enable the advancement of novel research molecules toward development of clinical candidates, which will ultimately lead to late‑stage development and commercialization. Ideal applicants will be agile and highly driven, collaborative, team‑oriented, possess excellent communication and organization skills, and carry a strong commitment to excellence.

Essential Functions And Responsibilities

• Perform HPLC and UPLC assays with minimal supervision including SEC and RP.
• Execute CE-SDS and iCIEF analysis for novel protein therapeutics and contribute to method optimization, qualification, and lifecycle management.
• Perform ELISAs for potency assessment.
• Perform DLS/SLS analysis using an UNcle instrument and generate datasets that will be used for formulation development studies.
• Perform subvisible particulate matter analysis by HIAC.
• Perform formulation development studies and execute clinical in‑use stability studies, transfer formulation knowledge internally.
• Design, conduct, analyze, interpret, and report laboratory experiments; summarize results for meetings and regulatory filings.
• Write and manage SOP’s and test methods.
• Manage and maintain required reagents, laboratory environment, and equipment needed to carry out assignments.
• Draft development reports, method qualification protocols, and method qualification reports
• Prepare presentations for team meetings.
• Work closely with team leaders to complete highest priority work to reach goals and milestones.
• Other duties as assigned.

Required Skills And Qualifications

• Bachelor’s degree and 4-6 years of relevant industry experience or a master’s degree with 3-5 years of relevant industry experience.
• Strong benchtop skills, experience with analysis of protein biologics and peptides.
• Proficiency with HPLC and UPLC assays; at least 3 years of experience is required. SEC and RP are desired.
• Experience with protein characterization techniques including CE-SDS, iCIEF, or related electrophoretic methods is preferred.
• Experience performing ELISAs is desired but not necessary
• Experience supporting analytical method qualification, comparability, stability, or formulation development studies is preferred.
• Demonstrated ability to analyze complex datasets, identify trends, troubleshoot experiments, and communicate scientific conclusions effectively.
• Ability to perform routine testing and to follow SOPs in a highly accurate and reproducible manner.
• Desire and ability to learn new technologies and explore new approaches to innovate.
• Training on project specific assays and ability to train others.
• Proven experience with writing and maintaining SOPs.
• Demonstrated ability to maintain accurate, complete, and contemporaneous experimental records in ELN systems in accordance with Good Documentation Practices (GDP).
• Ability to work independently; anticipates and solves problems in a proactive fashion.
• Must have excellent computer skills, and proficiency with Microsoft Excel and PowerPoint are required.
• Good oral and written communication skills a must.
• Excellent team player.

$95,000 - $108,000 a year

In addition to a competitive base salary ranging from $95,000 to $108,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.

Job Type

Full-time

Benefits

• Annual bonus program
• Incentive stock option plan
• 401k plan with flat non-elective employer contribution
• Comprehensive medical insurance with 90-100% employer-paid premiums
• Dental and vision insurance
• HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
• Unlimited PTO
• Generous holiday schedule; includes summer and winter company shutdown
• Relocation assistance

Schedule

• Monday to Friday

Work Authorization

• United States (Required)

Additional Compensation

• Annual targeted bonus %

Work Location

• On site (San Diego, CA)

Equal Opportunity Employer

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect theinterests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.