Senior Director, Clinical Operations

Janux Therapeutics; California (MO); Hybrid; USD 245,000 - 260,000; Full time

Benefits offered by this job

Annual bonus

Stock options

401(k) plan

Medical insurance

Dental & vision

HSA / FSA

Unlimited PTO

Holiday schedule

Relocation aid

Job summary

Janux Therapeutics seeks a Senior Director of Clinical Operations to lead global programs for innovative T‑cell engager therapies in immunology and oncology. You will drive study design, budgets, and cross‑functional execution across IND‑enabling and Phase 3 activities with CROs and internal teams.

The role demands senior leadership, strong regulatory knowledge, and a proven track record in complex clinical programs. Hybrid work in the U.S., with travel for site visits as needed.

Qualifications

• Bachelor’s degree in life sciences or related field with 12+ years of experience in clinical research, including at least 10 years in clinical trial management.
• Strong experience in complex autoimmune indications; early phase experience strongly preferred.
• Ability to define strategy and ensure organizational goals are executed in global clinical operations plans.
• Proven track record of leading complex clinical programs from start to completion.
• Strong knowledge of ICH GCP, FDA regulations, and global clinical regulatory guidelines.
• Strong IT skills in MS Office and clinical trial systems (e.g., CTMS, eTMF, EDC).
• Expertise in clinical budgeting and efficient allocation of resources.
• Demonstrated success in leading, mentoring, developing diverse clinical teams and providing oversight to CROs.
• Excellent communication, leadership, and interpersonal skills, including the ability to understand and present technical information effectively to executive leadership.
• Strong organizational and time‑management abilities.
• High level of accountability, adaptability, and attention to detail with an ability to set priorities and handle multiple tasks simultaneously in a changing environment.
• Ability to work independently and collaboratively in a fast‑paced, matrixed environment.

Responsibilities

• Drive global clinical operations strategy and execution for programs ensuring all clinical activities support IND‑enabling Phase 3 objectives, as well as future clinical development plans.
• Collaborate effectively cross‑functionally with senior leadership to ensure operational initiatives support strategic company goals.
• Establish and refine scalable best practices to drive efficiency while preparing for future departmental growth.
• Oversee the development, review, and operational implementation of study documents, including protocols, informed consent forms, CRFs, monitoring plans, and pharmacy manuals ensuring consistency among programs.
• Responsible for successful external partner relationships including CROs, central labs, patient advocacy groups and others. Ensure deliverables are met on time, within budget, and to quality standards.
• Prepare and deliver program updates, establish KPIs and dashboards, and effectively present to all study teams. Strongly represent Clinical Operations in internal and external meetings.
• Mentor and support direct reports, fostering professional development, team performance, and a strong culture.
• Oversee site strategy and establish Clinical Operations team relationships with investigators and key opinion leaders.
• Contribute to the development and implementation of SOPs, work instructions, and operational plans to enhance team efficiency and compliance.
• Develop and implement operational plans, timelines, and budgets for clinical programs.
• Ensure all trial activities are conducted in accordance with the protocol, SOPs, GCP, and applicable regulations.

Skills

Clinical operations leadership

IND- enabling Phase 3

ICH GCP knowledge

FDA regulations

Budgeting expertise

Mentoring teams

Cross-functional leadership

CTMS / eTMF

MS Office proficiency

Global program management

Stakeholder management

Education

Bachelor’s in life sciences

Advanced degree preferred

Tools

CTMS

eTMF

EDC systems

Clinical trial software

Job description

The Senior Director of Clinical Operations will provide global operational leadership overseeing complex clinical programs focusing on innovative T‑cell engager therapies for immunology and oncology indications. This role is responsible for efficient planning, resourcing, and execution of portfolio‑level programs in adherence to ICH‑GCP, FDA regulations, and company SOPs. The Senior Director will report to the Vice President, Clinical Operations and will ensure strategic alignment of programs and key stakeholder management in a fast‑paced environment, while mentoring and growing the Clinical Operations team and culture to ensure successful program delivery.

Essential Functions and Responsibilities

• Drive global clinical operations strategy and execution for programs ensuring all clinical activities support IND‑enabling Phase 3 objectives, as well as future clinical development plans.
• Collaborate effectively cross‑functionally with senior leadership to ensure operational initiatives support strategic company goals.
• Establish and refine scalable best practices to drive efficiency while preparing for future departmental growth.
• Oversee the development, review, and operational implementation of study documents, including protocols, informed consent forms, CRFs, monitoring plans, and pharmacy manuals ensuring consistency among programs.
• Responsible for successful external partner relationships including CROs, central labs, patient advocacy groups and others. Ensure deliverables are met on time, within budget, and to quality standards.
• Prepare and deliver program updates, establish KPIs and dashboards, and effectively present to all study teams. Strongly represent Clinical Operations in internal and external meetings.
• Mentor and support direct reports, fostering professional development, team performance, and a strong culture.
• Oversee site strategy and establish Clinical Operations team relationships with investigators and key opinion leaders.
• Contribute to the development and implementation of SOPs, work instructions, and operational plans to enhance team efficiency and compliance.
• Develop and implement operational plans, timelines, and budgets for clinical programs.
• Ensure all trial activities are conducted in accordance with the protocol, SOPs, GCP, and applicable regulations.

Required Education, Experience, Skills, and Abilities

• Bachelor’s degree in life sciences or related field with 12+ years of experience in clinical research, including at least 10 years in clinical trial management. Advanced degree preferred.
• Strong experience in complex autoimmune indications; early phase experience strongly preferred.
• Ability to define strategy and ensure organizational goals are executed in global clinical operations plans.
• Proven track record of leading complex clinical programs from start to completion.
• Strong knowledge of ICH GCP, FDA regulations, and global clinical regulatory guidelines.
• Strong IT skills in MS Office and clinical trial systems (e.g., CTMS, eTMF, EDC).
• Expertise in clinical budgeting and efficient allocation of resources.
• Demonstrated success in leading, mentoring, developing diverse clinical teams and providing oversight to CROs.
• Excellent communication, leadership, and interpersonal skills, including the ability to understand and present technical information effectively to executive leadership.
• Strong organizational and time‑management abilities.
• High level of accountability, adaptability, and attention to detail with an ability to set priorities and handle multiple tasks simultaneously in a changing environment.
• Ability to work independently and collaboratively in a fast‑paced, matrixed environment.

Compensation

$245,000 – $260,000 a year

In addition to a competitive base salary ranging from $245,000 to $260,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance may also be available. The hourly rate range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, and internal equity.

Job Type

Full‑time

Benefits

• Annual bonus program
• Incentive stock option plan
• 401(k) plan with flat non‑elective employer contribution
• Comprehensive medical insurance with 90–100% employer‑paid premiums
• Dental and vision insurance
• HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
• Unlimited PTO
• Generous holiday schedule, including summer and winter company shutdowns
• Relocation assistance

Schedule

• Monday to Friday

Work Authorization

• United States (Required)

Additional Compensation

• Annual targeted bonus (%)

Work Location

• Hybrid preferred in San Diego office. Remote permitted upon approval, with ability to travel up to 25% for meetings or site visits as required.

Equal Opportunity Employer

Janux Therapeutics, Inc. is an equal‑opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.