Senior Quantitative Pharmacologist

Regeneron Pharmaceuticals; Village of Tarrytown (NY); Hybride; USD 129 000 - 210 000; Plein temps

Résumé du poste

Regeneron Pharmaceuticals seeks a Senior Quantitative Pharmacologist to contribute to Pharmacometrics deliverables across programs, applying PK/PD principles and conducting analyses that inform development decisions. You will collaborate with PMx, statistics, and scientific writers to develop tables, figures, and reports.

The role supports regulatory interactions, prepares analyses for agency meetings, and requires a PhD with 3+ years' experience and expertise in population PK/PD and modeling

Qualifications

• PhD in Quantitative Pharmacology, Pharmacometrics, Engineering, or related field with 3+ years of experience.
• Expertise in population PK/PD, exposure–response, or mechanistic modeling using listed tools.
• Excellent communication and collaboration across technical and non-technical teams.

Responsabilités

• Collaborate across functions to plan, design, implement, and analyze PMx studies.
• Apply PK/PD data to evaluate and interpret in vitro and in vivo data.
• Conduct analyses including NCA, population PK, exposure–response, translational, and disease modeling.
• Interpret results and develop scientifically sound conclusions for development decisions.
• Prepare study reports, technical summaries, and regulatory submission documents.
• Partner with PMx researchers, programmers, statisticians, and writers for TFLs and supporting analyses.
• Contribute PMx expertise to GCST meetings, study design input, and result interpretation.
• Support regulatory interactions with analyses and background materials for agency meetings.
• Monitor timelines and deliverables; may serve as PMx representative on cross-functional teams.

Connaissances

Population PK/PD

Exposure–response

Mechanistic modeling

Interdisciplinary collaboration

Formation

PhD in Quantitative Pharmacology

Outils

NONMEM

Monolix

Simulx

MATLAB/Simbiology

R

Description du poste

Build Our Future Together

As a Senior Quantitative Pharmacologist this individual is expected to provide significant contributions to Pharmacometrics deliverables in support of multiple programs while also developing an ability to understand the strategic positioning for these programs in Pharmacometrics as well as across the organization. Through the application of state-of-the-art knowledge in pharmacokinetics and pharmacodynamics; is responsible for the execution of PK, PD, and other types of quantitative analyses that significantly contribute to the development of multiple programs.

When & where:

• Work Location: Tarrytown, NY, Warren, NJ, Cambridge, MA
• Work model/flexibility: 4 days per week onsite or remote

Discover your role:

• Collaborate across functions to plan, design, implement, and analyze pharmacometrics (PMx) studies supporting drug development programs.
• Apply standardized scientific approaches to evaluate and interpret in vitro and in vivo pharmacokinetic (PK), pharmacodynamic (PD), and PK/PD data.
• Conduct a broad range of quantitative analyses including NCA, compartmental modeling, population PK, exposure-response, translational, and disease modeling.
• Interpret study results and develop scientifically sound conclusions and recommendations to support development decisions.
• Prepare accurate, timely, and well-articulated study reports, technical summaries, and regulatory submission documents.
• Partner with PMx Research Specialists, programmers, statisticians, and scientific writers to develop tables, figures, listings (TFLs), and supporting analyses for internal and regulatory deliverables.
• Contribute PMx expertise to Research and Global Clinical Study Team (GCST) meetings, including input on study design, analysis strategy, and interpretation of results.
• Support regulatory interactions by preparing analyses and background materials for agency meetings, including pre-IND, End-of-Phase 2, and pre-BLA submissions.
• Monitor project timelines, deliverables, and completion of assigned tasks; may serve as the PMx representative on cross-functional development teams with appropriate guidance.
• Maintain compliance with PMx operating procedures, quality standards, and the company's code of ethical conduct.

This role requires:

• PhD in Quantitative Pharmacology, Pharmacometrics, Engineering, or a related field with 3+ years of experience
• Demonstrated expertise in population PK/PD, exposure–response, or mechanistic modeling (systems biology, or QSP) using tools such as NONMEM, Monolix, Simulx, MATLAB/Simbiology and R.
• Hands‑on experience with a broad range of quantitative and computational tools and a strong publication record.
• Exceptional communication and interpersonal skills, with the ability to influence and partner effectively across technical and non‑technical teams.

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/ . For other locations, additional information will be provided during the recruitment process.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$128,600.00 - $210,000.00