Senior Protein Scientist, Antibody Discovery (ORBIT)

University of Texas MD Anderson Cancer Center

Houston (TX)

On-site

USD 77,000 - 115,000

Full time

14 days+

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Benefits offered by this job

Medical coverage

PTO and holidays

Tuition assistance

Pension plan

Job summary

MD Anderson Therapeutics Discovery Division is seeking a motivated Institute Research Associate III to join the Protein Science team within ORBIT in Houston. You will contribute to discovery and development of novel anti-cancer biologics, focusing on recombinant protein and antibody expression, purification, and biophysical characterization to support lead optimization.

You will work under minimal supervision in a collaborative, multidisciplinary setting, communicating results to

Qualifications

Required: Bachelor's Degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Preferred: Master's Degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Experience: Three years research experience in a lab; with preferred degree, one year experience.
Experience with molecular cloning, recombinant DNA technologies, protein expression, purification and characterization, and antibody work.
The institution offers medical, dental, paid time off, retirement, tuition benefits and opportunities for professional growth.

Responsibilities

Under minimal supervision, conduct laboratory experiments to support antibody expression, characterization, lead identification, and lead optimization for therapeutic drug discovery programs.
Assist in design, development, execution, optimization, and validation of experiments and workflows for biologics discovery.
Perform recombinant protein and antibody expression, purification, and characterization using state-of-the-art techniques (BLI/Octet, FPLC, HPLC/SEC, UV, SDS-PAGE, Western blotting, LC-MS).
Design and optimize expression vectors and molecular constructs for recombinant proteins and antibodies, including high-throughput workflows.
Design, optimize, and perform RT-PCR assays using single cells and tissue samples to support antibody discovery and molecular characterization.
Analyze and interpret Sanger and NGS data to support antibody characterization and affinity maturation.
Maintain DNA clones and glycerol stocks; manage DNA prep and archiving.
Record, analyze, and maintain data; communicate findings to teams and management.