Senior Protein Engineer Scientist

Vertex; Seattle (WA); On-site; USD 90,000 - 130,000; Full time

Job summary

A leading company in Seattle is looking for a talented Protein Engineer (Senior Scientist) to advance scientific research and develop novel therapeutics. The role involves designing protein engineering campaigns, utilizing advanced technologies, and collaborating with interdisciplinary teams to optimize protein candidates.

Qualifications

• 2-5 years of relevant post-doctoral, industry employment experience for Ph.D. holders.
• 5+ years of relevant industry employment experience for M.S. holders.
• 8+ years of relevant industry employment experience for B.S. holders.

Responsibilities

• Design and execute protein engineering campaigns to improve binding affinity.
• Utilize yeast surface display technology for library screening.
• Prepare reports and collaborate with inventors and legal counsel.

Skills

Analytical Skills

Communication

Teamwork

Education

Ph.D. in Computational Biology

M.S. in Computational Biology

B.S. in Computational Biology

Tools

Rosetta Software Suite

Alphafold2

ColabFold

Protein MPNN

RFdiffusion

Job description

Our Seattle site is seeking a talented and motivated Protein Engineer (Senior Scientist) to join our dynamic team. If you are passionate about advancing scientific research and developing novel therapeutics, this role is for you!

Key Duties and Responsibilities :

• Design and execute protein engineering / directed evolution campaigns to improve binding affinity, stability, and selectivity.
• Utilize yeast surface display technology for library screening and directed evolution.
• Drawing from a deep array of Rosetta scripts and machine learning tools, create computational design strategies to deliver protein drug candidates.
• Effectively communicate design strategies to interdisciplinary team members.
• Collaborate with cross-functional teams to optimize protein candidates for function, manufacturability, and immunogenicity.
• Prepare reports, papers, and patent applications, collaborating closely with inventors, scientists, and legal counsel.

Knowledge and Skills :

• Strong understanding of the biophysics of protein structure / function relationships
• Proven experience in directed evolution, yeast surface display, and protein engineering.
• Demonstrated proficiency in protein modeling and design utilizing Rosetta software suite, Alphafold2, ColabFold, Protein MPNN, RFdiffusion or equivalent tools for insilico protein engineering
• Strong analytical skills and attention to detail
• Excellent communication and teamwork abilities
• Familiarity with antibody engineering and affinity maturation
• Experience in cellular assay development
• Understanding of cell biology and immunology

Education and Experience :

• Ph.D. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 2-5 years of relevant post-doctoral, industry employment experience, or
• M.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 5+ years of relevant industry employment experience, or
• B.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 8+ years of relevant industry employment experience

This position will be based out of our Seattle site location focused on protein engineering for the organization. Over the past 9 years we have utilized protein engineering to create a robust pipeline including Acazicolcept (ALPN-101) and Povetacicept (ALPN-303)