Senior Process Engineer, Upstream M

Piper Companies; Holly Springs (MS); On-site; USD 96,000 - 117,000; Full time

Benefits offered by this job

Medical, Dental, Vision

Paid Time Off

Long-Term Disability

Contract-to-perm potential

Job summary

Piper Companies is seeking a Senior Process Engineer to join a leading biopharmaceutical manufacturing organization on an onsite, long-term contract in Holly Springs, NC. The role supports upstream manufacturing operations and provides technical expertise for process optimization and troubleshooting.

Responsibilities include troubleshooting, process improvements, cross-functional collaboration across MSAT, Engineering, Automation, and Quality, and GMP-compliant investigations.

Qualifications

• Bachelor's degree in Chemical Engineering or related field preferred.
• 6–10 years biotech manufacturing or process engineering experience.
• Knowledge of upstream bioprocessing and large-scale operations.
• Hands-on experience with stainless steel bioprocess equipment.
• DeltaV experience highly preferred.

Responsibilities

• Provide technical support for upstream manufacturing operations (bioreactors, media prep, buffers, hold tanks).
• Troubleshoot process, equipment, and automation issues during campaigns.
• Drive process improvements to boost efficiency and performance.
• Collaborate with Manufacturing, MSAT, Engineering, Automation, and Quality.
• Analyze process data and support investigations in GMP environment.
• Offer hands-on floor support during production activities.

Skills

Upstream bioprocessing

Process troubleshooting

Manufacturing floor support

Cross-functional collaboration

Education

Bachelor's degree in Chemical Engineering or related field

Tools

DeltaV

Job description

Piper Companies is seeking a Senior Process Engineer to join a leading organization within the biopharmaceutical manufacturing industry. This is an onsite, long-term contract opportunity with strong potential for extension and conversion to a full-time employee, based in Holly Springs, NC. The Senior Process Engineer will support upstream manufacturing operations within one of the world's largest end-to-end cell culture manufacturing facilities, providing technical expertise for process optimization, troubleshooting, and manufacturing support.

Responsibilities of the Senior Process Engineer:

• Provide technical support for upstream manufacturing operations, including bioreactors, media preparation systems, buffer preparation systems, and hold tanks.
• Support active manufacturing campaigns by troubleshooting process, equipment, and automation-related issues.
• Drive process improvements and optimization initiatives to enhance manufacturing efficiency, reliability, and performance.
• Collaborate cross-functionally with Manufacturing, MSAT, Engineering, Automation, and Quality teams to resolve operational challenges.
• Analyze process data and support investigations, root cause analysis, and corrective actions within a GMP-regulated environment.
• Provide hands-on manufacturing floor support and technical guidance during production activities.

Qualifications for the Senior Process Engineer:

• Bachelor's degree in Chemical Engineering preferred, or a related field in other Engineering disciplines, Biotechnology, and Life Sciences
• 6-10 years of experience in biotech manufacturing, Process Engineering, MSAT, or related manufacturing support roles.
• Strong knowledge of upstream bioprocessing and large-scale manufacturing operations.
• Hands-on experience supporting stainless steel bioprocess equipment in a production environment.
• Demonstrated ability to troubleshoot manufacturing processes, equipment systems, and automation controls.
• Experience providing direct manufacturing floor support preferred over primarily CQV-focused experience.
• DeltaV experience is highly preferred.
• Background in process development or process sciences is a plus.

Compensation for the Senior Process Engineer:

• $70-$85/hour based on experience.
• Comprehensive Benefits: Medical, Dental, Vision, Life Insurance, Paid Time Off, Paid Holidays, and Long-Term Disability coverage.
• Long-term contract with strong potential to convert to a full-time employee.

Additional Details:

• Location: Holly Springs, NC (Onsite)
• Schedule: Monday-Friday, 8:00 AM - 5:00 PM ET
• Occasional evening support may be required during critical manufacturing activities; however, this is not expected to be frequent.

Keywords: Senior Process Engineer, Upstream Manufacturing, MSAT, Manufacturing Sciences and Technology, Biotech Manufacturing, Biopharmaceuticals, Cell Culture, Bioreactors, Media Preparation, Buffer Preparation, Stainless Steel Equipment, DeltaV, GMP, Process Optimization, Process Troubleshooting, Manufacturing Support, Upstream Processing, Process Engineering, Biotechnology, Large-Scale Manufacturing, Holly Springs, NC.

This position opened for applications on August 21, 2026, and will remain open for at least 30 days from the posting date.