Senior Process Engineer - Pharma Dosage & Digital Twin

AstraZeneca; Durham (NC); On-site; USD 110,000 - 160,000; Full time

Job summary

AstraZeneca in Durham seeks a Senior Process Engineer to lead development of robust manufacturing processes for oral solid dose and inhaled products. You will guide lab-scale studies, drive CPP definition, and support technology transfer and scale-up within a multidisciplinary product development team.

The role emphasizes digital tools, predictive modelling, and strong collaboration to accelerate development while ensuring product quality and compliance.

Qualifications

• Bachelors degree in chemical engineering, chemistry, or related field; 3+ years in industry.
• Experience in oral solid dose and/or inhaled drug product development.
• Experience across early-to-late stage development, tech transfer, scale-up and process validation.
• Fundamental understanding of control strategy and risk management.
• Basic understanding of predictive science, modelling and simulation.
• Demonstrated use of digital tools and process models for development.
• Excellent communication and collaboration skills.

Responsibilities

• Lead design and development of robust manufacturing processes for oral and inhaled products.
• Plan and execute lab-scale process development experiments to generate insights.
• Shape product development strategies with strong process understanding and control.
• Define and optimize CPPs and integrate them into control strategies.
• Lead or contribute to technology transfer, risk assessment, process validation, and scale-up.
• Apply modelling, simulation, digital twins, and predictive tools to strengthen understanding.
• Identify and solve complex technical challenges impacting project delivery.
• Promote creativity, innovation, collaboration, and scientific excellence.
• Partner across functions and own technical work packages within a multidisciplinary team.

Skills

Process engineering

Oral solid dose

Inhaled drug development

Technology transfer

Process validation

Risk management

Predictive modelling

Digital tools

Communication collaboration

Education

Bachelor's degree in Chemical Engineering/Chemistry

Tools

Digital twin software

Modelling tools

Job description

AstraZeneca in Durham seeks a Senior Process Engineer to lead development of robust manufacturing processes for oral solid dose and inhaled products. You will guide lab-scale studies, drive CPP definition, and support technology transfer and scale-up within a multidisciplinary product development team.

The role emphasizes digital tools, predictive modelling, and strong collaboration to accelerate development while ensuring product quality and compliance.